不同方法治疗重型复发性口腔溃疡的临床效果比较  

Comparison of effect on major recurrent aphtha with different methods of treatment

作　　者：陈洪[1] 何静[1] 周邵丽 张鹏恩[1] 

机构地区：[1]北海市人民医院口腔科,广西北海536000

出　　处：《广东牙病防治》2014年第1期18-21,共4页Journal of Dental Prevention and Treatment

摘　　要：目的探讨不同方法治疗重型复发性口腔溃疡的临床效果。方法选择重型复发性口腔溃疡患者90例,随机分成3组,分别使用中药治疗(中药组)、沙利度胺治疗(沙利度胺组)、中药联合沙利度胺治疗(联合治疗组),治疗期为4周,治疗结束后观察3组的近期疗效,1年后观察远期疗效;检测3组治疗前、治疗后、治疗后1年的TNF-α水平。结果中药组、沙利度胺组、联合治疗组治疗后的总有效率分别有73.3%、86.7%、93.3%,治疗后1年分别为70.0%、90.0%、93.3%,无论是近期疗效(χ2=37.472)还是远期疗效(χ2=7.247),3组总有效率的差异均具有统计学意义。中药组治疗前、治疗后、治疗后1年的TNF-α水平分别为(30.63±3.91)μg/L、(23.74±6.21)μg/L、(25.45±7.16)μg/L;沙利度胺组治疗前、治疗后、治疗后1年的TNF-α水平分别为(32.06±4.26)μg/L、(18.79±4.41)μg/L、(17.97±5.55)μg/L;联合治疗组治疗前、治疗后、治疗后1年的TNF-α水平分别为(31.48±4.36)μg/L、(16.26±5.31)μg/L、(15.93±5.74)μg/L。3组治疗后TNF-α水平均显著降低,联合治疗组治疗后和治疗后1年TNF-α水平均低于另外两组,差异均有统计学意义(P<0.05)。结论沙利度胺结合中药可有效治疗重型复发性口腔溃疡,值得临床推广。Objective To evaluate the clinical effect of different methods in the treatment of major recurrent aphtha. Methods Ninety individuals with major recurrent aphtha were divided into three groups randomly, Chinese herbal medicine was applied to the first group, and thalidomide was applied to the second group. Both Chinese herbal medicine and thalidomide were applied to the third group. After four weeks and one year, the curative effect of the three groups were recorded and compared, Serum levels of TNF-a of three groups with major recurrent aphtha were tested and compared before anti ＇after treatment, and one year after treatment. Results There was a significant difference of total effective rate in three groups （ P 〈 0. 05 ）. The serum TNF-a level of the three groups respectively was （30. 63 ± 3. 91 ） ug/L, （32.06 ±4.26） ug/L and （31.48 ± 4.36）ug/L before treatment. The serum TNF-ct level in the first group was （ 23.74 ± 6.21 ） ug/L after four weeks and that was （ 25.45 ± 7.16） ug/L after one year. The serum TNF-ot level in the second group was （ 18.79 ±4.41 ） ug/L after four weeks and that was （ 17. 97 ±5.55 ） ug/L after one year. The serum TNF-a level of the third group was （ 16.26 ±5.31 ） ug/L after four weeks and that was （ 15.93 ±5.74）ug/L after one year. The serum TNF-a level in third group was significantly reduced after treatment. There was a significant difference of the serum TNF-a level between the third group and the other two groups after treatment, either after four weeks or after one year （ P 〈 0. 05 ）. Conclusion Thalidomide with Chinese herbal medicine is effective to treat the major recurrent aphtha. It is worthing to extend its clinical application.

关 键 词：沙利度胺 中药 重型复发性口腔溃疡 

分 类 号：R781.5[医药卫生—口腔医学]