研究衰老标志物可从衰老生化本质出发  

Studies on the hallmarks of aging may start from the biochemical essence of aging

作　　者：印大中[1,2] 高军[1] 

机构地区：[1]暨南大学附属清远人民医院,广东清远511518 [2]蛋白质化学与发育生物学教育部重点实验室,湖南师范大学生命科学学院,湖南长沙410081

出　　处：《医学争鸣》2014年第2期28-30,共3页Negative

基　　金：国家高技术(863)研究发展计划项目(2008AA02Z411);国家自然科学基金项目(31271257)

摘　　要：衰老过程的本质是生物体内损伤与维护相拮抗的生化过程。2013年6月《Cell》发表的综述文章"衰老标志物"有重要缺陷并有误导之嫌。首先,研究真正意义上的衰老过程,应该将注意力集中在健康状态下的种种生理性老化改变,而不是仅仅关注DNA突变导致的病理性衰老变化。另外,生物体内蛋白质的增龄性损变和修饰是一个在健康百岁老人体内也普遍存在的应激生化导致的共性老化现象。总之,从衰老的熵增生化本质出发,衰老标志物及其相关研究才能有的放矢,事半功倍。The essence of aging is a biochemical process of damage vs maintenance in organisms. A review paper ＂The Hallmarks of Aging＂ published in Cell in June 2013 has important shortages and may induce misleading. First, to study real aging mechanisms, it is necessary focusing on physiological alterations instead of DNA mutation-resulted pathological events. Moreover, age-related aberration of proteins is most common alteration in healthy centenarians due to stress-induced biochemistry. In a word, when based on entropy-decided aging biochemistry, studies on aging hallmarks and related subjects can become accurate and efficient.

关 键 词：衰老 熵增 本质 生理性 

分 类 号：R363[医药卫生—病理学]