甘草酸磷脂复合物自乳化制剂对急慢性肝损伤的保护作用  

Experimental study on protective effect of Glycyrrhizic acid phospholipid complex self emulsifyingpreparation against acute and chronic liver injury

作　　者：茹仁萍[1] 包剑锋[1] 赵亚[1] 李松龙[1] 王琦[1] 梅笑冰[1] 刘寿荣[1] 

机构地区：[1]杭州市西溪医院杭州市第六人民医院,310023

出　　处：《中华实验和临床病毒学杂志》2014年第2期99-101,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的评价甘草酸磷脂复合物自乳化制剂（GA—PC—SE）对四氯化碳（CCl。）所致急性、慢性肝损伤的保护作用。方法大鼠、C57BL／6J小鼠腹腔注射CCl4复制急性肝损伤和慢性肝损伤模型，测定血清中天冬氨酸氨基转移酶（aspartate transaminase，AST）、丙氨酸氨基转移酶（alanine transaminase，ALT），并对肝脏进行病理学观察。结果甘草酸磷脂复合物自乳化制剂能降低急性肝损伤大鼠与慢性肝损伤小鼠AST、ALT水平（P〈0．01）。肝组织切片均显示甘草酸磷脂复合物自乳化制剂可以改善急性肝损伤大鼠与慢性肝损伤小鼠导致的肝细胞变性和损伤。结论甘草酸磷脂复合物自乳化制剂对CCl。所致肝损伤具有一定的保护作用。Objective To observe the effect of Glycyrrhizic acid phospholipid complex self emulsifying preparation against carbon tetrachloride induced acute and chronic liver injury in rats and C57 BL/ 6J mouse. Method A cute hepatic injury rat model and a chronic hepatic injury were established by intraperitoneal （ip） injection with carbon tetrachloride （ CC14 ） , the level of ALT and AST in serum were determined. The pathologic changes of hepatic tissue were observed with light microscope. Results The liver function results showed that Glycyrrhizie acid phospholipid complex self emulsifying preparation can significantly lower ALT and AST after acute and chronic liver injury （P 〈 0. 01 ）. Hepatic pathology study showed Glycyrrhizic acid phospholipid complex self emulsifying preparation could alleviate hepatic inflammation and effectively protect liver cells. Conclusion It was revealed that Glycyrrhizic acid phospholipid complex self emulsifying preparation could prevent carbon tetrachloride from inducing liver iniury.

关 键 词：甘草酸 肝疾病 病理学 

分 类 号：R575[医药卫生—消化系统]