磷脂酶D1,D2在日光性角化病、Bowen病和浸润性鳞状细胞癌中的表达及意义  

Expression of Phospholipase D1 and D2 in Actinic Keratosis,Bowen's Disease and Invasive Squamous Cell Carcinoma

作　　者：王小勇[1] 陶承军[1] 袁丞达[1] 王敏磊[1] 应航宇[1] 任金平[1] 

机构地区：[1]杭州市中医院皮肤科,浙江杭州310007

出　　处：《中国皮肤性病学杂志》2014年第5期451-453,460,共4页The Chinese Journal of Dermatovenereology

基　　金：2012年浙江省自然科学基金(LY12H11010)

摘　　要：目的探讨磷脂酶D(phospholipase D,PLD)1,2在日光性角化病、Bowen病和浸润性鳞状细胞癌中的表达及意义。方法应用免疫组织化学方法检测PLD1和PLD2在正常人皮肤组织、日光性角化病、Bowen病和浸润性皮肤鳞状细胞癌中的表达情况。结果与正常皮肤组织比较,日光性角化病、Bowen病和浸润性鳞状细胞癌中PLD1的表达水平显著降低(P均<0.05)。日光性角化病中PLD2的表达水平显著高于正常表皮(P<0.05),Bowen病和浸润性鳞状细胞癌的PLD2表达水平显著高于正常表皮(P均<0.05)和日光性角化病(P均<0.05)。结论 PLD1的表达下调和PLD2的表达上调与浸润性鳞状细胞癌的发生和发展可能相关。Objective To investigate the expression of phospholipase D1 （ PLD1 ） and D2 （PLD2） in lesions of actinic keratosis, Bowen＇ s disease and invasive squamous cell carcinoma.Methods Immunohistochemistry was used to detect the expression of PLD1 and PLD2 in tissue samples from normal human skin, actinic kerato- sis, Bowen＇s disease and invasive squamous cell carcinoma. Results Compared with the normal skin tis- sue, the expression of PLD1 decreased significantly in tissue samples from actinic keratosis, Bowen＇ s dis- ease and invasive squamous cell carcinoma respectively （all P 〈 0. 05）. Compared with the normal skin tis- sue, the expression of PLD2 increased significantly in tissue samples from actinic keratosis, Bowen＇ s disease, and invasive squamous cell carcinoma（all P 〈 0.05 ）. However, the expression of PLD2 increased signifi- candy in Bowen＇ s disease and invasive squamous cell carcinoma compared to actinic keratosis respectively （both P 〈 0. 05）. Conclusion The downregulated expression of PLD1 and upregulated expression of PLD2 may correlated with the carcinozenesis and orogression of invasive sauamous cell carcinoma.

关 键 词：磷脂酶D 日光性角化病 BOWEN病 鳞状细胞癌 

分 类 号：R739.5[医药卫生—肿瘤]