营养支持对非小细胞肺癌患者术前新辅助化疗后肺功能的影响  

Influence of lung function of pre-operation patients with stage ⅡB-ⅢA non-small cell lung cancer after neoadjuvant chemotherapy by nutrition support

作　　者：刘金锋[1] 田惠玉[1] 孙会凤 苗伏龙[1] 李志杰[1] 郭斌[1] 张会军[1] 

机构地区：[1]河北医科大学第一医院胸外科,河北石家庄050031

出　　处：《临床荟萃》2014年第5期518-520,共3页Clinical Focus

摘　　要：目的：探讨营养支持对ⅡB-ⅢA 期非小细胞肺癌（NSCLC）患者手术前新辅助化疗后肺功能的影响。方法收集50例术前ⅡB~ⅢA 期 NSCLC 患者，分为对照组和试验组各25例，对照组：普通饮食，行含紫杉类＋铂类方案化疗；试验组：在对照组基础上增加化疗期间的营养支持治疗；对化疗前、后的肺功能指标第1秒用力呼气量（FEV1）、最大分钟通气量（MVV）及弥散功能肺一氧化碳弥散量（DLCO）进行检测。结果两组化疗前肺功能指标差异均无统计学意义（P 〉0.05）；化疗后 DLCO 较化疗前有显著下降，差异有统计学意义（P 〈0.05）。试验组化疗后 FEV1、MVV 较化疗前及对照组化疗后有提高，差异有统计学意义（P 〈0.05）。结论术前化疗对肺弥散功能产生一定不良影响，有一定的肺毒性，营养支持能在一定程度上改善ⅡB-ⅢA 期非小细胞肺癌患者术前新辅助化疗后肺通气功能，但对肺弥散功能无显著影响。Objective To study the influence of lung function of pre-operation patients with stage ⅡB-ⅢA non-small cell lung cancer after neoadjuvant chemotherapy by nutrition support.Methods Fifty pre-operation patients with stage ⅡB-ⅢA non-small cell lung cancer were randomly divided into two groups：the control group （25 cases）：normal diet,containing paclitaxel ＋ platinum-based chemotherapy;experimental group （25 cases）：increased the nutritional support during the chemotherapy treatment on the basis of the control group;the lung function indexes were tested such as FEV1,MVV,DLCO before and after chemotherapy.Results The lung function indexes had no significant difference before chemotherapy between the control group and the experimental group （P 〉 0.05 ）;DLCO dropped significantly after the chemotherapy,the difference was statistically significant （P 〈 0.05 ）.FEV1,MVV in the experimental group relatively rose compared with pre-chemotherapy and the control group after chemotherapy（P 〈0.05 ）.＆amp;nbsp;Conclusion Preoperative chemotherapy has some influence on pulmonary diffusion function,there is certain lung toxicity.Nutrition support can improve pulmonary ventilation function of patients with stage ⅡB-ⅢA non-small cell lung cancer after preoperative neoadjuvant chemotherapy in some extent,but it has no significant effect on pulmonary diffusion function.

关 键 词：癌 非小细胞肺 呼吸功能试验 营养疗法 抗肿瘤联合化疗方案 

分 类 号：R730.26[医药卫生—肿瘤]