低剂量电离辐射对职业暴露人群染色体畸变率和微核细胞率影响的Meta分析  

Effect of low-dose radiation on frequencies of chromosome aberrations and micronucleus-containing cells of occupationally exposed individuals： a Meta analysis

作　　者：姜晶[1] 高露[1] 黄波[1] 周平坤[2] 让蔚清[1] 

机构地区：[1]南华大学公共卫生学院环境医学与放射卫生研究所,衡阳421001 [2]军事医学科学院

出　　处：《中华放射医学与防护杂志》2014年第4期250-254,共5页Chinese Journal of Radiological Medicine and Protection

基　　金：国家863项目（2012AA063501）;国家自然科学基金（81272994）

摘　　要：目的用Meta分析的方法综合定量分析电离辐射对职业暴露人群染色体畸变率和微核细胞率的影响。方法全面检索国内外中英文相关文献，按预先设定的纳入排除标准进行严格筛选后，最终纳入2I篇文献，总研究细胞数1970626个。用Stata12．0进行Meta分析，异质性检验用Q检验和，2统计量，发表偏倚用漏斗图法、Begg秩相关法和Egger线性回归法3种方法识别。结果放射工作人员发生染色体型畸变、双着丝粒体＋环状染色体畸变、易位、微核细胞的危险性要高于非放射工作人员，其比值比及95％的可信区间分别为3．03（2．59，3．56）、4．12（2．99，5．67）、2．73（1．67，4．46）、1．70（1．40，2．06）。结论长期暴露在低剂量电离辐射下会显著增加外周血淋巴细胞染色体畸变率和微核细胞率，应加强放射工作人员的辐射防护。Objective To quantitatively investigate the effect of low-dose ionizing radiation on the frequencies of ehromosome aberrations and micronucleus-containing cells of radiation workers. Methods Nine electronic databases were systematically searched on the basis of the published studies evaluating the effects of low-dose ionizing radiation on the frequencies of chromosome aberrations and mieronucleus- containing cells. Of the 195 studies searched, 21 studies were identified with a total of 1 970 626 cells under studying. Cochrane＇ s Q and 12 statistics were used to evaluate heterogeneity among studies and pooling odds ratio （OR） with 95% confidence intervals （CI） were calculated using random-effect models or fixed-effect models, and publication bias were also calculated. Meta-analysis was performed using Stata 12. 0. Results The pooling OR of chromosome-type aberrations [ OR = 3.03 （2.59,3.56） ], dicentric plus centric rings [ OR = 4. 12 （ 2.99,5.67 ） ], translocations [ OR = 2.73 （ 1.67,4.46 ） ], micronucleus- containing cells [ OR = 1.70 （ 1.40 - 2.06） ] were higher for radiation workers when compared with control group. Conclusions The frequencies of chromosome aberrations and micronucleus cell of peripheral lymphocytes are significantly high in radiation workers who were occupationally exposed to low-dose ionizing radiation. It should be noted that the radiation protection of radiological workers be enhanced.

关 键 词：放射工作人员 电离辐射 染色体畸变 微核细胞 META分析 

分 类 号：R144[医药卫生—公共卫生与预防医学]