温州市食品环境雌激素污染状况及风险评估  

Contamination levels of environmental estrogens in foods and risk assessment in Wenzhou

作　　者：赵娜娜[1] 应力[2] 孙方云 龙甲[3] 贺栋梁[3] 应晨江[3] 叶晓蕾[1] 

机构地区：[1]温州医科大学环境与公共卫生学院,浙江温州325035 [2]温州医科大学口腔医学院,浙江温州325035 [3]华中科技大学公卫学院营养与食品卫生系,湖北武汉430030

出　　处：《温州医学院学报》2014年第3期173-176,共4页Journal of Wenzhou Medical College

基　　金：国家自然科学基金资助项目(81030051)

摘　　要：目的 :检测温州市食品中主要环境雌激素的含量,评估膳食暴露风险。方法:随机抽取该市常见的肉类、水产类、蔬菜类和粮谷类食品,采用高效液相色谱-质谱串联法检测壬基酚(NP)、雌二醇(E2)、炔雌醇(EE2)、双酚A(BPA)的含量,结合当地人群的膳食结构,计算人群膳食暴露量,评估健康风险。结果:全部样品中均检出环境雌激素,NP检出率(100%)为最高,EE2检出率(49.3%)为最低,近1/4食品同时检出四种环境雌激素,同时检出2种及以上环境雌激素的食品占96.6%;居民平均膳食暴露风险指数分别为:NP 1.09×10-2,E2 0.41,BPA 1.84×10-4;最大风险指数分别为:NP 2.88×10-2,E2 1.20,BPA 8.58×10-4。结论:被检食品中绝大部分能同时检出2种以上环境雌激素;温州市食品中NP和BPA的健康风险指数小于1,尚属于安全范围;E2的暴露量已有一定风险。Objective： To determine the levels of environmental estrogens （ESs） in foods in Wenzhou, and perform an assessment of the health risk of ESs. Methods： Randomly selected items from categories of meat, fish/ shellfish products, vegetables and cereals of the city and the concentration of ESs, such as nonylphenol （NP）, bisphenol A （BPA）, ethinylestradiol （EE2） and estradiol （E2）, were determined by LC-MS/MS. Daily dietary exposure and health risk index of each estrogen were calculated considering the dietary pattern of the local people. Results： ESs were detected in all samples, the highest detection rate was of NP （100%） while the lowest was of EE2 （49.3%）. Four ESs were simultaneously detected in about 1/4 of the samples and two or more ESs were detected in 96.6% of foods. The average dietary exposure risk index of NP, EE2, and BPA were 1.09 × 10^-2, 0.41, and 1.84 × 10^-4 and the maximum dietary exposure risk index of NP, EE2, and BPA were 2.88 × 10^-2, 1.20, and 8.85 × 10^-4, respectively. Conclusion： Four ESs are detected in almost every food samples; The health risk index of NP, E2 and BPA is less than 1 in food samples in Wenzhou. But the exposure level of E2 may have risk to local residents.

关 键 词：环境雌激素 膳食暴露 风险评估 双酚A 壬基酚 

分 类 号：R155.51[医药卫生—营养与食品卫生学]