右美托咪啶对离体大鼠肠系膜动脉的作用  

Effects of dexmedetomidine on isolated rat mesenteric arterial rings

作　　者：马正敏[1] 景桂霞[1] 李小刚[1] 周荣胜[1] 

机构地区：[1]西安交通大学医学院第一附属医院麻醉科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2014年第3期329-332,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的研究右美托咪啶(dexmedetomidine,DEX)对血管平滑肌旳舒张作用,并探讨其作用机制。方法应用大鼠离体血管平滑肌张力记录法,观测DEX对大鼠离体肠系膜动脉环的作用及工具药对其作用的影响。结果 DEX对苯肾上腺素(PE,10-5 mol/L)预收缩的血管具有浓度依赖性的舒张作用,明显抑制由PE和KCl诱导的血管收缩,增加硝普钠诱导的血管舒张。在PE(10-5 mol/L)预收缩基础上,加入乙酰胆碱(ACh)不能抑制DEX的舒张血管效应。扩张血管作用与内皮无关。在无钙的生理盐水溶液中,DEX对CaCl2收缩血管有明显抑制作用。结论 DEX有舒张血管的作用,其作用不依赖于内皮细胞。Objective To investigate the dilating effect of dexmedetomidine （DEX） on isolated vascular smooth muscles and to explore the mechanism. Methods Tension of isolated mesenteric arterial rings of male Sprague-Dawley rats was recorded. The effects of DEX on the rings and the effects of DEX on vascular reaction induced by various drugs were recorded. Results DEX completely relaxed the contraction induced by phenylephrine （PE） and KC1 in a concentration-dependent manner in endothelium intact mesenteric arterial rings in rats. The vasodilating effect of DEX was increased by sodium nitroprusside. In phenylephrine （10^- 5mol/L） based on pre-vasoconstriction, adding acetylcholine could not suppress DEX＇s vasodilating effect. Vasodilation was not related to the endothelial cells. In physiological saline solution without calcium, DEX significantly inhibited the contraction induced by addition of CaCl2. Conclusion DEX can induce vasodilation in a concentration-dependent manner, which is not dependent on the endothelial cells.

关 键 词：右美托咪啶 大鼠 肠系膜动脉 血管舒张 

分 类 号：R57[医药卫生—消化系统]