EGFR、CTEN和E-cad在非小细胞肺癌中的表达及临床意义  

Expressions and clinical significance of EGFR,CTEN and E-cad in non-small cell lung cancer

作　　者：郭晓峰[1] 杨鲲鹏[1] 崔新征[1] 张清勇[1] 刘瑞来[2] 葛晓晴[1] 闫东[1] 常佳[1] 

机构地区：[1]郑州大学第二附属医院胸外科,河南郑州450014 [2]河北北方学院第一临床医学院外总实验室,河北张家口075000

出　　处：《西安交通大学学报（医学版）》2014年第3期346-351,共6页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：河南省卫生厅科技创新型人才基金资助项目(No.201003041)~~

摘　　要：目的探讨表皮生长因子受体(EGFR)、CTEN蛋白(CTEN)和E-钙粘附蛋白(E-cad)在非小细胞肺癌(NSCLC)中的表达及临床意义。方法采用免疫组化SP法检测EGFR、CTEN和E-cad在36例正常肺组织和82例NSCLC组织中的表达,并分析其与NSCLC的浸润、转移及预后的关系。结果 EGFR,CTEN和E-cad在82例肺癌组织中的阳性率分别为58.5%(48/82)、69.5%(57/82)和28.1%(23/82),在正常组织中的阳性表达率分别为13.9%(5/36)、0.0%(0/36)和100%(36/36),差异均有统计学意义(P<0.05);EGFR、CTEN和E-cad在NSCLC组织中的表达与肿瘤分化程度、TNM分期和淋巴结转移显著相关(P<0.05);NSCLC中EGFR与CTEN表达呈相关性(r=0.530,P<0.001),而E-cad与EGFR和CTEN表达呈相关性(r=0.499,P<0.001;r=0.333,P=0.001);多因素Cox回归分析显示,CTEN表达水平可作为NSCLC预后的独立因素(P<0.05)。结论 EGFR、CTEN和E-cad可能在NSCLC的发展、浸润、转移中起一定的作用;同时对预测NSCLC的预后具有一定的意义。ABSTRACT： Objective To explore the expressions and clinical significance of epidermal growth factor receptor （EGFR）, COOH-terminus tensin-like molecule （CTEN） and epithelial cadherin （E-cad） in non-small cell lung cancer （NSCLC）. Methods The expressions of EGFR, CTEN and E-cad in 36 cases of normal lung tissue and 82 cases of NSCLC tissues were observed with immunohistochemical SP method and their correlation with NSCLC invasion, metastasis and prognosis was analyzed. Results The positive rate of EGFR, CTEN and E-cad was 58.5% （48/82）, 69.5% （57/82） and 28.1% （23/82） in 82 cases of lung cancer, while 13.9% （5/36）, 0.0% （0/ 36） and 100% （36/36） in normal tissues; the differences were all significant （P〈0.05）. EGFR, CTEN and E-cad expressions in NSCLC tissues were significantly correlated with tumor differentiation, TNM stage and lymph node metastasis （P〈0.05）. The expressions of EGFR and CTEN were correlated with each other in NSCLC （r = 0. 530, P〈0. 001）, while the expressions of EGFR and CTEN were correlated with that of E-cad （ r = 0. 499, P〈0. 001 ; r=0.333, P = 0. 001）. Multivariate Cox regression analysis showed that CTEN expression in NSCLC was an independent prognostic factor （P 〈 0. 05）. Conclusion EGFR, CTEN and E-cad may play a role in the development, invasion and metastasis of NSCLC and have some significance in predicting the prognosis of NSCLC.

关 键 词：表皮生长因子受体 CTEN蛋白 E-钙粘附蛋白 非小细胞肺癌 预后 

分 类 号：R734.2[医药卫生—肿瘤]