苯扎氯铵的眼表毒性研究现状  

Toxicity research status of benzalkonium chloride on ocular surface

作　　者：黄彩虹[1] 陈文生[1] 陈永雄[1] 刘祖国[1] 

机构地区：[1]厦门大学眼科研究所福建省眼科与视觉科学重点实验室,361102

出　　处：《中华眼科杂志》2014年第4期303-306,共4页Chinese Journal of Ophthalmology

摘　　要：苯扎氯铵是滴眼液中最常用的防腐剂.至今有大量临床及实验研究表明,使用含苯扎氯铵的滴眼液会引起包括细胞凋亡在内的一系列眼表损伤.但最近有临床研究表明眼表正常的患者使用含苯扎氯铵的滴眼液后引起的眼表毒性与苯扎氯铵并无明显联系.有学者认为研究本身的局限性导致了人们对苯扎氯铵的毒性认识存在夸大之嫌.在此,我们总结了近年来有关苯扎氯铵临床及实验研究的众多资料,将对苯扎氯铵的眼表毒性研究现状作一综述.Benzalkonium chloride （BAC） is the most commonly used preservative in ophthalmic preparations.So far large bodies of clinical and experimental studies have shown that use of topical drugs containing BAC can induce a series of ocular surface diseases,such as apoptosis.However,recently,some clinical studies have shown that ocular toxicity in patients treated with eye drops containing BAC has not apparent correlated with BAC.Some scholars consider that the limitations of the research lead people to recognize the BAC toxicity exaggeratedly.Here we summarize numerous clinical and experimental studies of BAC in the past few years,and focus on reviewing recent researches of the toxic effect of BAC on ocular surfface.

关 键 词：苯扎胺化合物 眼药水 防腐剂 药物 眼表现 

分 类 号：R779.1[医药卫生—眼科]