多孔磷酸三钙修复腔隙性骨缺损38例随访研究  

Porous tricalcium phosphate for the repair of lacunar bone defects:a follow-up report of 38 cases

作　　者：许宋锋[1] 徐明[1] 于秀淳[1] 孙玉玺[1] 杨阳[1] 苏情[1] 胡睿[1] 翟永飞[1] 卢建熙 

机构地区：[1]济南军区总医院骨病科,250031 [2]上海贝奥路生物材料有限公司,200335

出　　处：《中国骨与关节杂志》2014年第4期282-286,共5页Chinese Journal of Bone and Joint

摘　　要：目的报告多孔磷酸三钙(tricalcium phosphate,TcP)治疗38例腔隙性骨缺损患者至少随访2年的临床效果。方法 2008年3月至2011年9月,对38例腔隙性骨缺损患者采用多孔磷酸三钙填充修复,男22例,女16例。年龄3~58岁,平均23岁。缺损范围最小0.72cm^3,最大151.88cm^3,平均35.62cm^3。随访25~65个月,平均41个月。采用在体TCP人工骨降解的x线片并图像分析软件分析植骨区灰度变化,计算材料降解率,动态观察多孔磷酸三钙人工骨降解情况。结果所有患者术后未见任何过敏或毒性反应。随时间延长,人工骨材料逐渐降解,新骨逐渐形成,以术后1年内降解速度最快。患者年龄越小(<16岁)、肿瘤体积越小(<10cm^3),新骨成骨、材料降解速度越快。结论多孔磷酸三钙人工骨可以用作良性或侵袭性骨肿瘤骨缺损的修复,平均随访41个月,疗效满意。Objective To assess the over-2-year clinical outcomes of porous tricalcium phosphate （ TCP ） for the repair of lacunar bone defects. Methods A total of 38 patients with lacunar bone defects underwent the repair with porous TCP from March 2008 to September 2011, including 22 males and 16 females, whose average age was 23 years old （ range;3-58 years ）. Tumor sizes varied from 0.72 cm3 to 151.88 cm3, with the average size of 35.62 cm3. All patients were followed up for a mean period of 41 months （ range;25-65 months ）. The in vivo biodegradation rate of the implanted TCP was evaluated based on the radiographic analyzing method. The gray scale change of the grafting area in plain X-ray images was used to assess the degradation of porous TCP. Results There was neither signiifcant reverse reaction to the transplanted material nor locally inlfammatory reaction in all of the cases. Bone defects were repaired gradually, in company with the degradation of TCP materials and the formation of new bone. The rates of TCP degradation and new bone formation were fastest in the ifrst year postoperatively. The younger the patients were （＆lt;16 years old ） and the smaller the tumor size was （＆lt;10 cm3 ）, the faster the rates were. Conclusions The porous TCP is an ideal material for the repair of lacunar bone defects caused by benign or invasive tumors, and the over-2-year follow-up results are satisfactory .

关 键 词：磷酸钙类 骨疾病 修复外科手术 生物医学研究 

分 类 号：R738.1[医药卫生—肿瘤]