TFIID在配子发生和早期胚胎发育过程中的作用  

The Role of TFIID in Gametogenesis and Early Embryonic Development

作　　者：郝国礼[1] 于海泉[1] 

机构地区：[1]内蒙古大学哺乳动物生殖生物学及生物技术教育部重点实验室,呼和浩特010070

出　　处：《中国细胞生物学学报》2014年第4期521-529,共9页Chinese Journal of Cell Biology

基　　金：内蒙古自然科学基金重大项目(批准号:2012ZD04)资助的课题~~

摘　　要：配子发生以及胚胎早期发育过程受严格且有序的基因表达调控。多种转录因子与靶基因结合,激活基因的时空特异性表达,实现受精卵全能性的获得,完成母型基因组转录调控向合子基因组转录调控的转变以及随后胚胎细胞的分化调节。研究表明,TFIID转录因子家族在这些关键阶段起重要作用,在基因转录调节的起始阶段,TFIID转录因子家族成员作为通用转录因子被招募到靶基因的启动子上,与其他转录因子共同形成转录前起始复合物,起始转录。该文总结了TFIID转录因子的结构、作用方式,以及在配子发生和早期胚胎发育中的调控作用。Gametogenesis and early embryonic development are regulated by precise and well-ordered gene expression. A variety of transcription factors bind to target genes to activate their expression in a spatially and tem- porally specific manner during these processes, which controls the acquisition of zygotic totipotency, the matemal to zygotic transition, and the regulation of embryonic cell differentiation. Previous studies have shown that trans- cription factor TFIID plays important roles in these development stages. Before the initiation of gene transcription, subunits of TFIID are recruited to target gene promoters, and form pre-initiation complexes with other transcription factors to initiate transcription. This review summarizes the structure and action mechanism of TFIID, as well as its regulatory roles in gametogenesis and early embryonic development.

关 键 词：TFIID 配子发生 合子基因组激活 基因标签 

分 类 号：Q75[生物学—分子生物学]