脊髓小脑共济失调3型患者血清神经标志物水平的改变及其临床意义  

Changes and their clinical significances of serum levels of neural biochemical markers in patients with spinocerebellar ataxia type 3

作　　者：陈余雪[1] 于蕾[2] 金寅[1] 李楠[1] 李岚[3] 赵莉[1] 顾卫红[4] 董春波[1] 

机构地区：[1]大连医科大学附属第一医院神经内科,116011 [2]大连市友谊医院神经内科 [3]大连医科大学附属第二医院神经内科 [4]北京中日友好医院神经内科

出　　处：《临床神经病学杂志》2014年第2期84-87,共4页Journal of Clinical Neurology

摘　　要：目的研究脊髓小脑共济失调3型（SCA3）患者血清神经标志物水平的改变及其临床意义。方法用国际协作共济失调评估量表（ICARS）对21例SCA3患者（SCA3组）进行评分。采用放射免疫法检测SCA3组患者和22名正常对照者（正常对照组）的血清神经元特异性烯醇化酶（NSE）、SIOOB蛋白（S100B）、胰岛素样生长因子1（IGF-1）及其结合蛋白3（IGFBP-3）水平。并对SCA3患者血清神经标志物水平与年龄、发病年龄、病程、CAG重复数、ICARS评分的关系作Spearman相关分析。结果与正常对照组比较，SCA3组血清NSE水平明显升高，血清IGF-1、IGFBP-3水平明显降低（P〈0．05—0．005）。Spearman相关分析显示，SCA3患者血清NSE水平与病程、ICARS评分呈正相关（r=0．585，r=0．627，均P〈0．05），血清S100B水平与CAG重复数呈正相关（r=0．619，P〈0．01），与年龄、ICARS评分呈负相关（r=-0．574，r=-0．539，均P〈0．05）。结论SCA3患者的血清NSE、1GF-1、IGFBP-3水平有显著改变，血清NSE和S100B水平与其病程、病情有明显关系。血清神经标志物可反映SCA3患者的病程及病情程度。Objective To investigate the changes and their clinical significances of serum levels of neural biochemical markers in patients with spinocerebellar ataxia type 3 （SCA3）. Methods The international cooperative ataxia rating scale （ICARS） was used to assess 21 SCA3 patients （SCA3 group）. Serum concentrations of neuron- specific enolase （NSE）, proteins S100B （S100B）, insulin-like growth factor-1 （IGF-1） and its binding protein 3 （IGFBP-3） were measured in SCA3 group and 22 healthy subjects （normal control group） by radioimmunoassay method. The correlations among those markers and age, age of onset, disease duration, CAG repeat number and ICARS scores were analyzed by Spearman analysis. Results Compared with normal control group, the serum level of NSE in SCA3 group were significantly increased, while the serum levels of IGF-1 and IGFBP-3 were significantly decreased （ P 〈 0. 05 - 0.005 ）. Spearman analysis showed that the serum level of NSE in SCA3 group was positive correlated with the disease duration and the ICARS scores （r = 0. 585, r = 0. 627, all P 〈 0. 05 ） ; the serum level of S100B was positive correlated with the CAG repeat number （ r = 0. 619, P 〈 0. 01 ）, while negative correlated with the age and the ICARS scores （r = - 0. 574, r = - 0. 539, all P 〈 0. 05）. Conclusions The serum levels of NSE, IGF-1 and IGFBP-3 are significantly changed in SCA3 patients. The serum levels of NSE and S100B are correlated with the disease duration and the severity of SCA3 patients. The serum levels of neural biochemical markers can reflect the disease progression and the severity of SCA3 patients.

关 键 词：脊髓小脑共济失调3型 神经元特异性烯醇化酶 SIOOB蛋白 胰岛素样生长因子1 胰 岛素样生长因子结合蛋白3 

分 类 号：R744[医药卫生—神经病学与精神病学]