血浆D-二聚体水平与急性脑梗死患者预后的关系  

Correlation of the plasma D-dimer level and the prognosis of patients with acute cerebral infarction

作　　者：王晶[1] 刘晶晶[2] 刘金凤[1] 郭兆慧[1] 李红丽[1] 

机构地区：[1]哈尔滨市第一医院神经内科,150010 [2]首都医科大学附属北京安贞医院神经内科

出　　处：《临床神经病学杂志》2014年第2期123-124,共2页Journal of Clinical Neurology

基　　金：黑龙江省卫生厅科研项目(2010-308);哈尔滨市科技创新人才基金(2011RFQYS071)

摘　　要：目的探讨血浆D-二聚体水平与急性脑梗死患者预后的关系。方法采用乳胶免疫比浊法检测673例急性脑梗死患者血浆D-二聚体的含量。并于发病30d时对患者进行改良Rankin量表评分，评定预后。对不同预后患者的结果进行比较分析。结果发病30d时，mRS评分0—2分（预后良好组）342例；mRS评分3～6分（预后不良组）331例。预后不良组患者血浆D-二聚体水平[（386．56±31．22）μg/L]明显高于预后良好组[（379．84±33．71）μg／L]（P〈0．01）。Logistic回归分析显示，血浆D-二聚体水平升高是急性脑梗死患者预后不良的独立危险因素（OR=2．423，95％CI．1．537—3．862，P〈0．05）。结论血浆D．二聚体水平升高是急性脑梗死患者预后不良的独立危险因素。Objective To investigate the correlation of the plasma D-dimer level and the prognosis of patients with acute cerebral infarction. Methods The plasma D-dimer levels of 673 patients with acute cerebral infarction were detected by Latex immune turbidimetry. The prognosis was evaluated according to the modified Rankiu Scale （mRS） scores at 30 d after onset. The results were compared and analyzed. Results At 30 d after onset, patients with mRS 0 -2 scores were 342 cases （good prognosis group） ; while patients with mRS 3 -6 scores were 331 cases （poor prognosis group）. The plasma D-dimer level in poor prognosis group [ （386.56 ± 31.22）μg/L] was significantly higher than that in good prognosis group [ （ 379.84 ± 33.71 ） μg/L] （ P 〈 0.01 ）. Logistic analysis showed that the increase of plasma D-dimer level was the independent risk factor of poor prognosis of patients with acute cerebral infarction （OR=2.423, 95%CI： 1.537 -3.862, P〈0.05）. Conclusion The increase of plasma D-dimer level is the independent risk factor of poor prognosis of patients with acute cerebral infarction.

关 键 词：D-二聚体 急性脑梗死 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]