外周血单核细胞数量与肺癌放疗近、远期疗效的相关性分析  

Correlation analysis between peripheral blood mononuclear cells and radiotherapy effect in lung cancer

作　　者：徐燕梅[1] 崔天祥[1] 张晓晶[1] 李德志[1] 孙建国[1] 

机构地区：[1]第三军医大学新桥医院全军肿瘤诊治研究所,重庆400037

出　　处：《中华肺部疾病杂志（电子版）》2014年第2期29-33,共5页Chinese Journal of Lung Diseases(Electronic Edition)

基　　金：国家自然科学基金资助项目(81272496);重庆市自然科学基金(cstc2012jjB0076);第三军医大学校管课题(2011D264)

摘　　要：目的基于外周血单核细胞（pbMXD）迁徙在肿瘤放疗后复发中的重要作用，探讨pbMXD在监测肺癌放疗近、远期疗效中的价值。方法回顾性分析肺癌放疗患者，随访观察其放疗前后血象变化、pbMXD变化与近、远期疗效的相关性。结果105例肺癌患者，整体客观缓解率（RR）61．9％（65／105），中位无进展生存期（PFS）5．0个月（1～20．3个月）；28例局部晚期非小细胞肺癌（NSCLC），同步放化疗组RR为66．7％（8／12），PFS6．5个月（1．5—14．2个月）。两类资料中，放疗前、后pbMXD绝对值、相对值及变化值与RR和PFS均无显著相关性（P〉0．05）；pbMXD最低值与整体NSCLC和局部晚期NSCLC单纯放疗组的近期疗效相关（P〈0．05）。结论NSCLC放疗中，pbMXD最低值对预判近期疗效有一定价值，阻断pbMXD迁徙或有较好临床前景。Objective Based on the migration of peripheral blood mononuclear cells （pbMXD） plays an important role in tumor recurrence after radiotherapy, we further study its value in monitoring lung cancer radiotherapy effect. Methods Retrospective analysis the routine blood before and after radiotherapy in lung cancer, observe the correlation between pbMXD and short, long-term curative effect. Results The overall radiation effective rate （RR） was 61.9%, and the median progression-free surial （PFS） was 5 months （1- 20.3 months） in 105 lung cancer cases. In the 28 cases of locally advanced NSCLC, the RR was 66.7%, and the median PFS was 6.5 months （ 1.5-14.2 months） in the concurrent chemoradiotherapy group. There has no significant correlation between absolute, relative and changing values of pbMXD with RR or PFS （P 〉 0. 05 ）. The minimum pbMXD has correlation with overall NSCLC and locally advanced NSCLC in simple radiotherapy group （P 〈 0. 05 ）. Conclusions In NSCLC radiotherapy, the minimum pbMXD has a certain value in monitoring short-term effect, and block the migration of pbMXD or has a good clinical prospect.

关 键 词：支气管肺癌 外周血单核细胞 放射治疗 疗效分析 预后 

分 类 号：R734.2[医药卫生—肿瘤]