艾司西酞普兰对急性缺血性卒中患者运功功能恢复的影响  

Effect of escitalopram on motor recovery after acute ischemic stroke

作　　者：詹奕红[1] 童绥君[1] 安星凯[1] 鲁丛霞[1] 马琪林[1] 

机构地区：[1]厦门大学附属第一医院神经内科,福建厦门361003

出　　处：《中国医院药学杂志》2014年第9期752-755,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察艾司西酞普兰对急性缺血性卒中患者运动功能恢复的影响。方法:选择90例急性缺血性卒中伴运动功能缺损患者,随机分成2组,分别接受艾司西酞普兰与安慰剂,连续治疗90 d。采用傅格梅尔运动量表(FMMS)、美国国立卫生研究院卒中量表(NIHSS)和汉密顿抑郁量表(HAMD)评定患者治疗前后运动功能缺损、神经功能缺损及抑郁程度;治疗结束后评定患者的脑卒中后抑郁发生率。结果:治疗前2组FMMS、NIHSS、HAMD评分差异无统计学意义(P>0.05)。在治疗结束后,艾司西酞普兰组FMMS评分明显高于安慰剂组(P<0.01),NIHSS评分、HAMD评分明显低于安慰剂组(P<0.01);卒中后抑郁发生率也明显低于安慰剂组(P<0.01)。结论:早期应用艾司西酞普兰治疗有利于急性缺血性卒中伴运动功能缺损患者运动功能的恢复,并能预防卒中后抑郁的发生。OBJECTIVE To observe the effect of escitalopram on motor recovery after acute ischemic stroke. METHODS 90 patients with acute ischemic stroke and motor deficit were randomly assigned to escitalopram （n = 45） or place- bo （n= 45） for 90 days. Before and after treatment, we assessed Fugl-Meyer motor scale （FMMS）, National Institues of Health Stroke Scale （NIHSS） and Hamilton Depression Scale （HAMD）of all patients. Moreover the both groups were as- sessed the rate of post-stroke depression at the end of treatment. RESULTS The FMMS, NIHSS, HAMD scores of the two groups before treatment were not significantly different （P〉0. 05）. At the end of treatment, the escitalopram group had lower rate of post-stroke depression than the placebo group （P〈0. 01）, higher score in FMMS （P〈0. 01 ）, lower score in NIHSS （P〈0. 01） and lower score in HAMD （P〈0. 01）. CONCLUSION In patients with acute ischemic stroke and motor deficit, the early prescription of escitalopram enhanced motor recovery after 90 days and decreased the rate of post-stroke depression.

关 键 词：艾司西酞普兰 5-羟色胺再摄取抑制剂 急性缺血性卒中 运动功能恢复 

分 类 号：R969[医药卫生—药理学]