HPV58与宫颈癌研究进展  

Progress on Human Papillomavirus Type 58 Research of Cervical Diseases

作　　者：朱佳妮[1] 丁爱萍[1] 张淑兰[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,沈阳110004

出　　处：《国际妇产科学杂志》2014年第2期137-141,共5页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(81372776);辽宁省医学高峰建设工程项目(2010696);辽宁省科学技术计划项目(2011225009);盛京自由研究者计划(200806);沈阳市科学技术计划项目(F11-262-9-15)

摘　　要：高危型人乳头瘤病毒(HPV)的持续感染已被证实是宫颈癌及癌前病变发生的必要但非充分原因。HPV58是高危型HPV之一,并且感染HPV58在亚洲地区极其常见。就HPV58的流行病学特点、HPV58的感染过程和致癌机制、HPV58的整合状态与致癌性等进行综述。亚洲地区妇女的宫颈病变中,HPV58阳性率很高,尤以中国突出。其中,HPV58基因变异在其感染与地理分布及恶变的过程中有重要作用。另外,HPV58的E6和E7原癌基因高表达保留了宿主细胞的复制功能,使细胞永生化,在上皮细胞转化过程中起到关键作用。并且,HPV58基因整合到宿主基因是宫颈病变恶性转化的关键步骤。因此,考虑到HPV58在中国的高分布,关于HPV58基因变异,流行病学特点,病毒整合和病毒原癌基因等方面的大样本多来源的研究是今后主要的研究方向。High risk human papillomavirus （HPV） plays a necessary,though insufficient,role in the development of cervical cancer. As one of the high risk HPVs ,HPV58′s infection is very common in East-South Asian area. Thus ,our review mainly focuses on the epidemiology ,carcinogenicity and viral integration of HPV58. We found out that as one of the high risk HPV types,HPV58 is rare worldwide but being found more commonly in East Asia. E6,E7 of HPV58 are the major oncoproteins,which are responsible for the transformation of host cells. Moreover,the integration of HPV58 to the host cell also plays an important role in the transformation of host cells. Thus ,a clear study is of a great significance to the research of the pathogenesis of HPV58 in cervical carcinoma and precancerous lesions and the health of Asian women. Therefore the epidemiology,carcinogenicity and viral integration of HPV58 will be the new host research hot spots.

关 键 词：乳头状瘤病毒科 宫颈肿瘤 癌 原癌基因 病毒整合 流行病学 

分 类 号：R737.33[医药卫生—肿瘤]