微孔淀粉在丁香挥发油固化中的应用研究  

Study on Solidifying Clove Volatile Oil with Microporous Starch

作　　者：马琍琍 李舒新[2] 滕家良[3] 

机构地区：[1]南京晨光集团有限责任公司晨光医院药剂科,南京210006 [2]中国药科大学药学院,南京210009 [3]江苏省省级机关医院药剂科,南京210024

出　　处：《药学与临床研究》2014年第1期47-49,共3页Pharmaceutical and Clinical Research

摘　　要：目的:研究微孔淀粉吸附丁香挥发油的特性。方法:采用微孔淀粉吸附丁香挥发油,考察微孔淀粉用量对丁香酚收率、溶出度和热稳定性的影响。结果:微孔淀粉和挥发油质量比为2.5∶1时,固化粉末中丁香酚收率达到(91.03±0.56)%,丁香酚体外溶出度增加,热稳定性改善。结论:微孔淀粉适于固化丁香挥发油,具有推广价值。Objective： To characterize the adsorption capacity of microporous starch, taking clovevolatile oil as the model drug. Methods： The yield and dissolution rate of eugenol from different ratio ofmicroporous starch were evaluated, meanwhile the thermal stability of eugenol was studied. Results： Theyield of eugenol was up to （91.03±0.56）% when solidification ratio of microporous starch to volatile oil was2.5：1; meanwhile the dissolution rate of eugenol was increased and the thermal stability was improved afterabsorption by porous starch. Conclusion： The above results proved that the microporous starch is suitablefor solidifying clove volatile oil, which paved the preliminary way for the study of microporous starch asabsorbent and solidifying excipient.

关 键 词：微孔淀粉 丁香挥发油 溶出度 稳定性 

分 类 号：R943[医药卫生—药剂学]