Lin28/Let-7调节环分子机制及相关因子研究进展  

Molecular mechanism and related influence factors of Lin28/Let-7 axsis

作　　者：饶丽华 黄孝文[2] 许胜[3] 

机构地区：[1]宜昌市第二人民医院耳鼻咽喉头颈外科,湖北宜昌443000 [2]华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科 [3]湖北省妇幼保健院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2014年第9期663-665,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：Micro RNAs（miRNAs）是一种内源性、非编码的单链小分子RNA,长度为21-25nt（少数小于20nt）〔1〕。人类Let-7miRNA家族包括Let-7a-1、7a-2、7a-3、7b、7c、7d、7e、f7-1、7f-2、7g、7i、miR-98和miR-202等,是细胞完全分化的标记〔2〕。There are 13 members of the Let -7 miRNAs family which is regarded as tumor suppressor gene, locating in nine different chromosome loci. Lin28 acts as negative regulatory factor of miRNA biological recurrence. By selectively blocking the processing synthesis of the Let-7 miRNAs family, Lin28 block the inhibition effect of miRNA of proto-oncogenes and interact with RNA helicase to enhance gene translation at the same time. By not quite clear mechanism, an up-regulation of Let-7 inhibits the expression and function of Lin28. In more and more studies of human tumor, Lin28/Let-7 axsis was proved to be important significance of the tumorts occurrence and development. In this paper,we research briefly the recent progress of the molecular mechanism and related in- fluence factors of Lin28 / Let-7 axsis.

关 键 词：Lin28 Let-7miRNAs 原癌基因 抑癌基因 

分 类 号：R739.6[医药卫生—肿瘤]