影响补铁剂脂质体芯材泄漏的因素探讨  

Factors influence core material leakage of iron supplement liposomes

作　　者：丁保淼[1] 

机构地区：[1]长江大学生命科学学院,湖北荆州434025

出　　处：《中国食品添加剂》2014年第2期120-123,共4页China Food Additives

基　　金：湖北省教育厅科学技术研究项目(Q20131204);湖北省高等学校青年教师深入企业行动项目(XD2012143)

摘　　要：为明确在贮藏期间,内外界因素对补铁剂脂质体芯材泄漏的影响,以芯材泄漏率为指标研究了壁材组成、芯材含量、pH、温度、金属离子、离子强度等贮藏条件对补铁剂脂质体芯材泄漏的影响。实验结果表明,壁材组成(蛋黄卵磷脂∶胆固醇,EPC∶CHOL,w/w)为8∶1,芯壁比(w/w)为1∶10,pH为6.8,温度为4℃,一价金属离子,离子强度为0.05 mol/L等条件下,补铁剂脂质体泄漏较慢,有利于补铁剂脂质体的稳定性;同时,随着贮藏时间的延长,芯材泄漏率增加。这为提高贮藏期间补铁剂脂质体的稳定性、增加其实际应用价值提供了理论依据。The effects of inner-exterior factors on core-material-leakage of iron supplement liposomes were investigated during the storage period.Core material leakage ratio was used as the indicator,and the effects of technical parameters （such as wall-material composition,core-to-wall material ratio,pH,temperature,metal ions,ion strength） on core material leakage of iron supplement liposomes were studied by single factor analysis.The results showed that：the leakage was very slow under the condition of wall-material composition 8 ∶ 1,core-to-wall material ratio 1 ∶ 10,pH 6.8,temperature 4 ℃,metal ions Na＋/K＋,ion strength 0.05 mol/L.Furthermore,the leakage increased by the storage period.The results provided the theory for improving the stability and application of iron supplement liposomes.

关 键 词：脂质体 补铁剂 包封率 泄漏率 微柱离心法 

分 类 号：TS202.3[轻工技术与工程—食品科学]