Association between serum homocysteine and arterial stiffness in elderly： a community-based study  

作　　者：Song ZHANG Yong-Yi BAI Lei-Ming LUO Wen-Kai XIAO Hong-Mei WU Ping YE 

机构地区：[1]Department of Geriatric Cardiology, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing 100853, China [2]School of Medicine, Nankai University, N0.94, Weijin Road, Tianjin 300071, China

出　　处：《Journal of Geriatric Cardiology》2014年第1期32-38,共7页老年心脏病学杂志（英文版）

基　　金：grants from the Key National Basic Research Program of China，Nature Science Foundation of China (81270941) to Ye P,and the Nature Science Foundation of China，the Beijing Nova Program (Z121107002513124) to Bai Y

摘　　要：Background Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older popula tions. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. Methods We related serum levels of homocysteine to two measures of arte- rial stiffness （carotid-femoral pulse wave velocity （PWV） and carotid-radial PWV） in 780 participants （46.3% men, mean age 71.9 years （ranging 65-96 years old）） from two communities of Beijing, China. Arterial stiffness were measured within two days of the time of bio- marker measurement. Results In multiple-adjusted models, homocysteine levels was strongly associated with the carotid-femoral PWV （standardized 13 = 0.13, P 〈 0.001）, even after adjustment for classical risk factors of cardiovascular disease. The association is also stronger when the carotid-femoral PWV is elevated above normal, whereas no significant association with homocysteine was observed for ca-rotid-radial PWV. Conclusions In Chinese elderly persons, serum homocysteine levels are associated with alterations of aortic stiffness.

关 键 词：The elderly HOMOCYSTEINE Arterial stiffness Pulse wave velocity 

分 类 号：Q517[生物学—生物化学] O351.2[理学—流体力学]