PCNA和MMP-9在食管鳞癌中的表达及其意义  

Expression and significance of PCNA and MMP-9 in esophageal squamous cell carcinomas

作　　者：程冕[1] 韩敏辉[1] 王宁燕[1] 

机构地区：[1]解放军第123医院九病区,安徽蚌埠233015

出　　处：《淮海医药》2014年第3期213-215,共3页Journal of Huaihai Medicine

摘　　要：目的分析PCNA,MMP-9在食管鳞癌中的表达,探讨其在食管鳞癌发生发展中的意义。方法应用免疫组化方法检测PCNA,MMP-9在52例食管鳞癌和30例癌旁组织中的表达情况,并结合临床病理资料进行分析。结果PCNA,MMP-9蛋白在食管鳞癌组织中的表达率高于癌旁组织,差异具有统计学意义(P<0.05)。PCNA的表达与食管鳞癌的分化程度,淋巴结转移有关;MMP-9的表达与食管鳞癌分化程度,肿瘤浸润程度,淋巴结转移及临床分期相关;PCNA和MMP-9表达呈正相关(P<0.05)。结论食管鳞癌组织中PCNA,MMP-9的高表达参与了肿瘤的发生发展,联合检测有助于食管鳞癌恶性生物学行为的判断和病程的评估。Objective To study the expression of PCNA and MMP-9 in esophageal squamous cell carcinomas and validate the significance in the tumorigenesis and progression. Methods The expression of PCNA and MMP-9 in 52 esophageal squa- mous cell carcinomas tissues and 30 adjacent non-neoplastic tissus were detected with immunohistoehemical maxvision method, and the results were analyzed combined with clinical pathologic data. Results The positive rate of PCNA and MMP-9 in e- sophageal squamous cell carcinomas tissues were higher than that in adjacent non-neoplastic tissus （ P 〈 0.05 ）. The expression of PCNA was correlated with differentiation of tumor and lymphnode metastasis. The expression of MMP-9 was correlated with differentiation of tumor, lymphnode metastasis, depth of invasion and clinical TNM types. In addition, there was a positive corre- lation between the expression of PCNA and MMP-9 （ P 〈 0.05 ）. Conclusion The high expression of PCNA and MMP-9 in e- sophageal squamous cell carcinomas may play a crucial role in the tumorigenesis and progression. Combined detection may con- tribute to evaluation of the malignant biological behaviour and prognosis.

关 键 词：食管肿瘤 增殖细胞核抗原 基质金属蛋白酶-9 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]