海藻酸钙/聚精氨酸微胶囊的载药和缓释性能  

Drug loading and release of poly-L-arginine/calcium alginate microcapsules

作　　者：吴文果[1,2] 刘伟[1] 王士斌[1,2] 刘源岗[1,2] 陈爱政[1,2] 

机构地区：[1]华侨大学化工学院,福建厦门361021 [2]生物材料与组织工程研究所,福建厦门361021

出　　处：《化工进展》2014年第5期1271-1275,共5页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金项目(81301290;31170939)

摘　　要：采用乳化-固化法,制备海藻酸钙/聚精氨酸微胶囊。分别考察不同聚精氨酸相对分子质量、海藻酸钠浓度、氯化钙浓度对海藻酸钙-聚精氨酸微胶囊载药量以及牛血红蛋白缓释性能的影响。实验结果表明,中相对分子质量聚精氨酸制备的海藻酸钙/聚精氨微胶囊的载药量较高并且具有更好的缓释效果。随着海藻酸钠浓度的升高,海藻酸钙/聚精氨微胶囊的载药量降低;随着氯化钙浓度的升高,海藻酸钙/聚精氨微胶囊的载药量先升高后略有降低;然而,以上因素对海藻酸钙/聚精氨微胶囊的缓释性能均无明显影响。Poly-L-arginine/calcium alginate microcapsules were prepared by emulsification-gelation. The influences of different concentrations of sodium alginate and calcium chloride as well as different molecular weights of poly-L-arginine on drug loading and controlled-release of bovine haemoglobin in microcapsules were investigated. The microcapsules with medium molecular weight of poly-L-arginine had higher drug-loading amount and better controlled release behavior. The drug-loading amount of microcapsules decreased with the increase of sodium alginate concentration. As the concentration of calcium chloride increased,the drug-loading amount firstly increased and then decreased slightly, however,the release properties were not obviously affected.

关 键 词：乳化-固化法 海藻酸钠 聚精氨酸 微胶囊 缓释 

分 类 号：R318[医药卫生—生物医学工程]