OCB、抗MBP抗体及抗MOG抗体在中枢神经系统炎性脱髓鞘疾病诊断中的意义  

Significance of oligoclonal bands,myelin basic protein antibody and myelin oligodendrocyte glycoprotein antibody in diagnosis of inflammatory central nervous system demyelinating diseases

作　　者：覃惠洵[1] 刘琳琳[2] 郝洪军[2] 高枫[2] 

机构地区：[1]广西柳州市人民医院神经内科,柳州545005 [2]北京大学第一医院神经内科,北京100034

出　　处：《中国实用神经疾病杂志》2014年第8期11-13,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的通过观察中枢神经系统炎性脱髓鞘疾病患者寡克隆区带(OCB)、抗髓鞘碱性蛋白(MBP)抗体及抗髓鞘少突胶质细胞糖蛋白(MOG)抗体的阳性率,为临床诊断提供一定的参考。方法入组91例中枢神经系统炎性脱髓鞘疾病患者为观察组(其中MS 30例,NMO 61例)及50例神经系统非炎性病变患者为对照组。首先分析观察组与对照组间OCB、脑脊液及血清中抗MBP抗体、抗MOG抗体阳性率的差异,再分析观察组中MS亚组及NMO亚组间上述指标阳性率的差异。结果 2组比较,OCB、血清抗MBP抗体及血清抗MOG抗体阳性率比较差异有统计学意义(P<0.05),脑脊液抗MBP抗体及脑脊液抗MOG抗体阳性率比较差异无统计学意义(P>0.05)。MS亚组与NMO亚组,OCB、血清抗MBP抗体阳性率比较差异有统计学意义(P<0.05),脑脊液抗MBP抗体、血清抗MOG抗体及脑脊液抗MOG抗体阳性率比较差异无统计学意义(P>0.05)。结论 OCB阳性对诊断MS具有重要意义。血清抗MBP抗体及抗MOG抗体可为中枢神经系统炎性脱髓鞘疾病的诊断提供重要实验室依据,血清抗MBP抗体在MS与NMO的鉴别诊断中具有一定价值。Objective To observe the positive rate of oligoclonal bands （OCB） ,myelin basic protein （MBP） antibody and myelin oligodendrocyte glycoprotein （MOG） antibody in patients of inflammatory central nervous system demyelinating disea-ses ,in order to give help to clinical diagnosis in these kind of diseases.Methods The observation group consisted of 91 cases of inflammatory central nervous system demyelinating diseases （30 cases of MS and 61 cases of NMO） ,and the control group con-sisted of 50 cases of neurological non-inflammatory diseases. The statistical analysis was developed on data of the positive rate of OCB ,MBP and MOG antibody in cerebrospinal fluid and serum between the observation group and control group. The same statistical analysis was also developed between the MS subgroup and NMO subgroup.Results Between the observation group and control group ,the positive rate of OCB ,serum MBP and MOG antibodies were significantly different （P〈0.05） ,and the positive rate of cerebrospinal fluid MBP and MOG antibodies were not significantly different （P〉0.05）. Between the MS sub-group and NMO subgroup ,the positive rate of OCB and serum MBP antibody were significantly different （P〈0.05） ,and the positive rate of cerebrospinal fluid MBP antibody ,serum MOG antibody and cerebrospinal fluid MOG antibody were not signifi-cantly different （P〉0.05）.Conclusion The positive OCB is significant in diagnosis of MS. The serum MBP antibody and ser-um MOG antibody provide an important laboratory basis for the diagnosis of inflammatory central nervous system demyelinating diseases. The serum MBP antibody is probably valuable in differential diagnosis of MS and NMO.

关 键 词：寡克隆区带 髓鞘碱性蛋白 髓鞘少突胶质细胞糖蛋白 炎性脱髓鞘 多发性硬化 视神经脊髓炎 

分 类 号：R744.51[医药卫生—神经病学与精神病学]