急性脑梗死患者外周血CD133^+细胞动态变化及意义  

The dynamic changes and significance of the level of peripheral blood CD34 positive cells in patients with acute cerebral infarction

作　　者：周华[1] 赵中[1] 谢红娜[1] 

机构地区：[1]南京医科大学附属苏州医院神经内科,苏州215000

出　　处：《中国实用神经疾病杂志》2014年第8期16-18,共3页Chinese Journal of Practical Nervous Diseases

基　　金：苏州市科技发展计划(项目编号:SYS201049)

摘　　要：目的探讨急性脑梗死患者外周血CD133+细胞的动态变化及其在评价脑梗死预后中的意义。方法采用流式细胞仪测定发病72h以内的急性期脑梗死患者(梗死组80例)和有脑血管危险因素但无脑梗死发生的患者(对照组40例)外周血CD133+细胞水平,并记录脑梗死患者入院时、3d、7d和14d外周血CD133+细胞水平和患者神经功能缺损评分(NI HSS评分)。结果急性梗死患者外周血CD133+细胞百分比低于对照组,差异有统计学意义(P<0.05),且急性脑梗死患者外周血CD133+数量逐渐上升,第7天达高峰,脑梗死患者第7天CD133+细胞上升值与NI HSS评分改善值呈负相关(r=-0.673,P<0.05)。结论急性期脑梗死患者1周后外周血CD133+细胞明显升高提示预后良好,CD133+细胞对预测脑梗死预后具有一定意义。Objective To explore the dynamic changes and significance of the level of peripheral blood CD133 positive （CD133＋ ） cells in patients with acute cerbral infarction.Methods The level of peripheral blood CD133＋ cells was determined by flow cytometrywithin 72 hours of onset of patients with acute cerebral infarction （infarct group ,n= 80）and patients with cerebrovascular risk factors without cerebral infarction （control group ,n=40）. The neural function deficit score were deter-mined in patients with infarction group.Results The percentage of peripheral blood CD133＋ cells in infarction patients was lower than that in the control group ,the difference was statistically significant （P〈0.05）. And the increment of the level of percentage of CD133＋cells in peripheral blood of patients was negatively correlated with the improvement in NIHSS score at day 7 （r= -0.673 ,P〈0.05）.Conclusion The increase of the level of percentage of CD133＋cells in peripheral blood after acute ischemic stroke is associated with good functional outcome. And＆amp;nbsp;the level of percentage of CD133＋cells in peripheral blood has certain significance in predicting cerebral infarction outcome.

关 键 词：CD133+ 急性脑梗死 流式细胞仪 内皮祖细胞 

分 类 号：R743.33[医药卫生—神经病学与精神病学]