丹参注射液与保肝药物联合治疗酒精性肝病的Meta分析  

Meta-Analysis of the Therapeutic Effect of Salvia Injection Combined With Liver Protection Drugs in Treatment of ALD

作　　者：陈蕊[1] 刘志军[1] 程悦[1] 卢添林 许欣[1] 

机构地区：[1]四川大学华西公共卫生学院,四川成都610041

出　　处：《现代临床医学》2014年第2期103-105,共3页Journal of Modern Clinical Medicine

摘　　要：目的：评价丹参注射液与现有保肝类药物联合治疗酒精性肝病的安全性和有效性。方法：利用计算机检索PubMed、OVID、万方、维普和CNKI数据库中收录的2012年9月之前发表的关于丹参与保肝药物联合治疗酒精性肝病的随机对照试验（RCT）或临床试验文献,使用RevMan5.2.1软件对纳入文献进行分析。结果：联合用药的总体效果合并OR（95%CI）值为5.72（2.22~6.17）;联合用药组和对照组总不良反应发生率分别为2.94%和0。结论：丹参与保肝药物联合用药能够明显改善酒精性肝病患者肝脏生化指标和体征,存在不良反应,但发生率较低。Objective： To evaluate the therapeutic effect and safety of Salvia injection combined with general liver protection drug in the treatment of alcoholic liver disease （ALD）. Methods：These articles about randomized controlled trial （RCT） of Salvia injection combined with general liver protection drugs in the treatment of ALD were retrieved in databases of including PubMed, OVID, Wanfang Data, VIP and CNKI. RevMan5.2. 1 software was applied for meta -analysis. Results： There was significant difference in overall effect between combination group and control group （OR = 5.72,95% C1：2.22 -6.17 ）. There was significant difference between combination group and control group in the adverse reaction （2.94% and 0）. Conclusion： The Salvia injection combined with general liver protection drugs can improve the biochemical indicators of liver function and clinical symptoms of patients with ALD, have low adverse effect rate.

关 键 词：丹参注射液 联合用药 酒精性肝病 META分析 

分 类 号：R575[医药卫生—消化系统]