维生素C联合维生素K3抗肿瘤作用的研究进展  

Research progress of anti-tumor effect of vitamin C combined with vitamin K3

作　　者：刘祚仁(综述)[1] 郭塨(审校)[1] 

机构地区：[1]中南大学湘雅医学院附属三医院神经外科、湖南省长沙市中心医院神经外科,长沙410013

出　　处：《肿瘤研究与临床》2014年第4期280-283,共4页Cancer Research and Clinic

基　　金：湖南省医药卫生科研课题计划湖南省医药卫生科研课题计划（B2012.132）

摘　　要：维生素C（vC）和维生素K3（VK3）在抗氧化、提高机体免疫力和止血等方面被广泛应用.20世纪40年代,人们发现它们也具有抗肿瘤作用.研究表明,VC与VK3联合给药比例为100：1时,具有最佳的协同抗肿瘤作用,并能大幅降低剂量,不会增加机体的不良反应.能够对乳腺癌、卵巢癌、前列腺癌、膀胱癌、白血病等多种肿瘤细胞产生杀伤作用.这种组合已被申请了专利并进行了Ⅰ/ⅡA期临床试验,试验结果表明其能延长晚期癌症患者的生存时间,不良反应轻,具有广阔的应用前景.文章就VC联合VK3的协同抗肿瘤作用进行综述.Vitamin C （VC） and vitamin K3 （VK3） are widely used in the fields of antioxidant,immunity improvement and hemostasis,etc.In the 1 940 s,the antitumor effect of these two vitamins was found.Research shows that the combination regimen of VC and VK3 with a ratio of 100：1 produces a maximum of synergistic anti-tumor effect.Such combination reduces the overall dose of drugs,thus avoiding the increase in their adverse effects.The combination of VC and VK3 effectively kills a variety of tumor cells,such as breast cancer,ovarian cancer,prostate cancer,bladder cancer and leukemia,etc.This combined therapy has been patent and is in phase Ⅰ and Ⅱ clinical trials.The clinical studies show that it prolongs the survival time of patients with terminal cancer,while its adverse reactions is mild.Therefore,VC in combination of VK3 is of broad application prospect.This paper reviews the synergistic anti-tumor effects of VC combined with VK3.

关 键 词：肿瘤 维生素C 维生素K3 

分 类 号：R730.51[医药卫生—肿瘤]