小剂量HA方案治疗老年急性髓细胞性白血病临床观察  

Clinical Observation of Low-dose HA Regimen in the Treatment for Elderly Patients with Acute Myeloid Leukemia

作　　者：俞庆宏[1] 沈一平[1] 叶宝东[1] 周郁鸿[1] 

机构地区：[1]浙江中医药大学附属第一医院,浙江杭州310006

出　　处：《中国肿瘤》2014年第5期435-437,共3页China Cancer

基　　金：国家中医临床研究基地业务建设科研专项("抗白延年汤"联合小剂量化疗治疗老年急性髓系白血病的临床研究)的组成部分(DZX2012176);临床注册号:Chi-CTR-TRC-13003671

摘　　要：[目的]研究小剂量HA方案治疗老年急性髓细胞白血病（AML）的临床疗效及安全性。[方法]应用小剂量HA方案（高三尖杉酯碱每天1mg，静脉滴注，第1-14d；阿糖胞苷12．5mg，皮下注射每12h一次．第1～14d；4周为1个疗程）治疗初发的老年急性髓细胞性白血病患者10例，1个疗程后观察疗效及毒副反应。[结果]10例患者中，完全缓解6例（60％），部分缓解1例（10％）．总有效率为70％。骨髓抑制相对较轻，未见严重的非血液系统毒副反应。[结论]小剂量HA方案诱导缓解治疗老年AML具有较好的有效率，毒副反应耐受较好，可作为年龄较大、一般状况较差、有多种或较重合并症的老年AML患者的初始治疗方案选择。[ Purpose ] To observe the efficacy and toxicity of low-dose HA regimen （homoharringtonine and cytarabine） for elderly acute myeloid leukemia. [Methods] A total of 10 untreated AML elderly patients were treated by the low-dose HA regimen （ homoharringtonine lmg iv qd,days 1-14 ;cytara- bine 12.Smg ih ql2h,days 1-14,4 weeks as a eycle）.The clinical response was assessed after 1 cycles of chemotherapy.[Resultsl Of the 10 cases,6 cases achieved complete remission（CR）; 1 case, partial remission（PR）;and 3 cases,non-remission（NR）. The total remission rate was 70%.Myelosuppression was the most frequent toxicity,it was mild relatively,no severe non-hematologic toxicity was oc- curred. [Conclusion ] Low-dose HA regimen achieves a better response for elderly AML patients with acceptable toxicity. It could be a choice of the initial therapeutic regimen for eiderly AML patients with severe complication or poor performance status.

关 键 词：小剂量HA方案 急性髓细胞性白血病 老年人 疗效 

分 类 号：R733.7[医药卫生—肿瘤]