血同型半胱氨酸水平与颈动脉斑块及急性脑梗死的相关性研究  

Relationship between Plasma Level of Homocysteine and Carotid Plaques in Acute Cerebral Infarction

作　　者：李贵阳[1] 牟方波[2] 张法伟[2] 郭鹏[2] 

机构地区：[1]潍坊医学院 [2]山东省潍坊医学院附属潍坊市中医院

出　　处：《中西医结合心脑血管病杂志》2014年第3期311-312,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的研究血同型半胱氨酸(Hcy)水平与颈动脉斑块及急性脑梗死的关系。方法对100例急性脑梗死患者与70名健康对照者进行空腹血Hcy水平测定,并进一步行彩超检查颈动脉内膜厚度及斑块,将急性脑梗死组分为颈动脉斑块组和无颈动脉斑块组;比较急性脑梗死组与对照组以及急性脑梗死组中两亚组的血Hcy水平。结果急性脑梗死组血Hcy浓度为(21.59±4.72)μmol/L,明显高于对照组(10.01±3.69)μmol/L,差异有统计学意义(P<0.05)。急性脑梗死组中有颈动脉斑块者血Hcy浓度为(22.35±4.67)μmol/L,明显高于无颈动脉斑块者血Hcy浓度(17.64±2.53)μmol/L,差异具有统计学意义(P<0.05)。结论高Hcy血症与颈动脉斑块形成有关,是急性脑梗死的危险因素之一。Objective To explore the relationship between plasma level of homocysteine(Hcy)and carotid plaques in patients with acute cerebral infarction(ACI).Methods A total of 100patients(experiment group)with acute cerebral infarction were divided into carotid plaques group and non-carotid plaques group,and 70healthy subjects were as control group.Plasma levels of Hcy were measured,and carotid plagues in carotid artery were assessed by color Doppler ultrasound.Results Plasma levels of Hcy was 21.59μmol/L± 4.72μmol/L in experiment group and 10.01μmol/L±3.69μmol/L in control group.Plasma levels of Hcy and incidence rate in carotid plaques group were significantly higher than those in control group(P<0.05).Plasma level of Hcy(22.35μmol/L±4.67 μmol/L)in carotid plaques group was significantly higher than that in non-carotid plagues(1 7.6 4μmol/L±2.5 3μmol/L,P< 0.05).Conclusion Hyperhomocysteinemia was related to the formation of carotid plaques,which was the risk factors of acute cerebral infarction.

关 键 词：急性脑梗死 血同型半胱氨酸 颈动脉斑块 颈动脉内膜-中层厚度 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R255.2[医药卫生—临床医学]