响应面优化白芷总香豆素提取工艺的研究  

Optimization of Extraction Technology of Taotal Coumarins from Angelica Dahurica by Response Surface Methodology

作　　者：蓝耀宏[1] 

机构地区：[1]广西南宁地区教育学院,广西南宁530001

出　　处：《化工技术与开发》2014年第2期20-24,共5页Technology & Development of Chemical Industry

摘　　要：采用响应面法优化并确定白芷总香豆素的乙醇提取工艺。利用单因素试验方法,以白芷总香豆素的含量作为评价指标,研究乙醇浓度、乙醇用量、提取时间对白芷总香豆素提取量的影响,同时利用Design-Expert 8.0.7.1响应面分析统计学方法构造模型,优化并确定白芷总香豆素的乙醇提取工艺。确定白芷总香豆素乙醇提取工艺的最优提取条件为:提取时间为4.23h,乙醇浓度为62.1%,固液比为1∶382。通过实验结果对模型进行验证,实验值与理论值的相对误差为0.60%,说明模型可靠性高,可作为白芷工业化规模提取的工艺借鉴。The total coumarin angelica ethanol extraction process was optimized and obtained by response surface methodology. Using single factor test method, angelica total content of coumarin as the evaluation index, the ethanol concentration and ethanol, extraction time on the extraction of angelica total amount of coumarin were studied. Design-Expert 8.0.7.1 response surface analysis of statistical method was used to construct the model, optimize and determine the total coumarin angelica ethanol extraction process. The total coumarin ethanol extraction process angelica optimal extraction conditions were： extraction time of optimum conditions 4.23h, ethanol concentration was 62.1%, solid-liquid ratio of 1：382. The results validated the model, experimental and theoretical values of the relative error of 0.60%, indicated that the model high reliability could be used as industrial-scale extraction process Angelica reference.

关 键 词：白芷香豆素 乙醇提取 单因素实验 响应面优化 

分 类 号：R284.2[医药卫生—中药学]