侵袭性血管黏液瘤的临床病理特点——附16例病例分析  

The clinical and pathological features of aggressive angiomyxoma: an analysis of 16 cases

作　　者：郭瑞江[1] 齐跃[1] 刘水策[1] 刘娟娟[1] 刘冰莹[1] 张丹晔[1] 周欣[1] 林蓓[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2014年第3期660-663,共4页Journal of Modern Oncology

基　　金：盛京自由研究者计划(编号:200807)

摘　　要：目的:探讨侵袭性血管黏液瘤(aggressive angiomyxoma,AAM)患者的临床、病理特点、诊治方法及预后。方法:回顾性分析2006年至2013年中国医科大学附属盛京医院收治的16例AAM患者的临床资料,对其临床及病理特点、诊断治疗方法及预后进行分析。结果:患者年龄18-77岁(平均42.58岁),其中女性14例,男性2例。16例患者多无明显症状,多以发现包块逐渐增大为主诉(外阴、臀部9例,下肢2例),其次为无症状、仅体检发现包块(4例,其中2例后期出现下腹坠痛),尿频1例。部分增强CT及增强MRI可见特异性的"旋涡状"或"分层"结构,病理切片可见形态基本一致的星芒状、卵圆形或短梭形的瘤细胞,亦可见扩张的薄壁或厚壁血管。16例均行手术治疗,1例术后补充1次化疗,随访10例,1例术后复发,失访6例。结论:AAM虽然属于良性肿瘤,但术后复发率高,需定期随访。治疗以手术为主,亦可考虑GnRH-a治疗。Objectlve：To investigate the clinical,pathological features,diagnosis,treatment methods and prognosis of aggressive angiomyxoma（AAM） patients. Methods：Retrospectively analyzed the clinical files of the 16 AAM eases in Shengjing Hopital of China Medical University from 2006 to 2013 ,the clinical and pathological features, diagnosis and treatment methods and prognosis were reviewed. Results：Of the 16 eases,the mean age was 42.58 years （range： 18 -77 years） ,14 females and 2 males. Most of the eases showed gradually enlarged mass（vulva and gluteal region 9 eases,lower limbs 2 eases） and no other obvious symptoms was complained,some eases found mass just after body ex- anaination（4 eases,in which 2 eases showed lower abdominal pain after examination） , 1 ease showed frequent mieturi- tion. Some enhanced CT and MRI showed specific “ whirlpool” or “ stratified” structure. Pathological section showed starry,owl or spindle - shape tumor cells, and some dilated thin - or thick - walled vessels, All these 16 eases re- ceived operation,in which 1 ease accompanied with successive chemotherapy,10 eases were followed up,1 ease reoc- curred after operation,6 eases were lost. Conclusion： AAM is a benign tumor with high recurrence after operation and a strict follow - up is needed. The main treatment method is surgical operation and GnRH - a treatment should also be considered to some operation - intolerance patients.

关 键 词：侵袭性血管黏液瘤 CT MRI 病理 治疗 

分 类 号：R732.3[医药卫生—肿瘤]