MMP-9、TIMP-2和VEGF与非小细胞肺癌风险性关联研究  

Study on risk correlations among MMP-9,TIMP-2,VEGF and non-small cell lung cancer

作　　者：路德荣 顾世玉[1] 张丽萍[1] 

机构地区：[1]新乡医学院第三附属医院消化内科,河南新乡453003

出　　处：《中国民康医学》2014年第4期21-23,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:在非小细胞肺癌(NSCLC)中,基质金属蛋白酶-9(MMP-9)及基质金属蛋白酶抑制剂-2(TIMP-2)和血管内皮细胞生长因子(VEGF)的表达及其意义。方法:采用免疫组织化学法检测70例NSCLC中MMP-9、TIMP-2和VEGF的表达水平和分布情况,以及与淋巴结转移的相关性。结果:MMP-9、TIMP-2和VEGF在NSCLC中的表达水平明显高于正常对照组,有统计学差异(P<0.05);MMP-9和VEGF在淋巴结转移组中的表达水平明显高于无淋巴结转移组,有统计学差异(P<0.05),TIMP-2在有淋巴结转移组表达水平高于无淋巴结转移组,但无统计学差异(P>0.05)。结论:MMP-9、TIMP-2和VEGF的过度表达与NSCLC的发展、淋巴结转移及预后有密切关系,在NSCLC浸润转移中发挥重要作用,MMP-9、TIMP-2和VEGF均可作为预测NSCLC临床预后的生物学标志物,其联合检测更有意义。Objective：To determine expression of matrix metalloproteinase-9（MMP-9）, tissue inhibitor of metalloproteinase-2 （TIMP-2） and vascular endothelial growth factor（VEGF） in non-small cell lung cancer（NSCLC） and their significance. Meth-ods：Immunohistochemical method was used to check the expressions and distributions of MMP-9, TIMP-2 and VEGF in 70 NSCLCpatients. Further, the correlations among the expressions and distributions of MMP-9, TIMP-2 and VEGF and lymphatic metastasiswere studied. Results： In NSCLC, the expressions of MMP-9, TIMP-2 and VEGF were obviously higher than those in control group,and the difference had statistical significance （P〈0. 05）. The expressions of MMP-9 and VEGF were obviously higher in the groupwith lymphatic metastasis than those in the group without lymphatic metastasis, and the difference had statistical significance （P〈0.05）. The expression of TIMP-2 was higher in the group with lymphatic metastasis than that in the group without lymphatic metastasis,but the difference had no statistical significance （P〉0. 05）. Conclusions： The excessive expressions of MMP-9, TIMP-2 and VEGFhave obvious relativity with NSCLC development, lymphatic metastasis and prognosis. It might play an important role in the infiltrationand metastasis of NSCLC. MMP-9, TIMP-2 and VEGF might be good indices of metastasis and prognosis in NSCLC. Therefore, thecombined detection is of significance.

关 键 词：MMP-9 TIMP-2 VEGF 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]