同步放化疗在中晚期宫颈癌中的应用进展  

A application progress of concurrent chemoradiotherapy in medium-term and advanced cervical cancer

作　　者：甘祖焕 甘浪舸[1] 谭毅[1] 

机构地区：[1]广西医科大学第一附属医院放疗科,南宁530021

出　　处：《中国临床新医学》2014年第4期371-376,共6页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：同步放化疗治疗中晚期宫颈癌较单纯放疗能提高总生存率和无进展生存率,降低复发率,改善预后。同步放化疗不是简单的放疗与化疗相加,化疗不仅能杀死癌细胞,杀灭肿瘤亚临床病灶,同时对放疗有增敏作用。同步放化疗机制可能是化疗抑制肿瘤细胞放疗后损伤的修复,减少对放疗不敏感的乏氧细胞的比例和促使肿瘤细胞同步化进入对放疗敏感的细胞周期。目前大多数研究者认为使用以顺铂为基础的同步放化疗方案效果更佳。同步放化疗较单纯放疗的毒副作用相对较大,具体使用仍处于摸索阶段。The chemoradiotherapy for medium-term and advanced cervical cancer has better efficacy than the pure radiotherapy to improve overall survival rate and progression free survival rate ,it can reduce the recurrence rate and improve prognosis .Chemoradiotherapy is not a simple radiotherapy combined with chemotherapy and chemothera -py can not only kill cancer cells and tumor subclinical lesions , also increase sensitivity of cancer cells to radiothera-py.Chemoradiotherapy mechanism may be：chemotherapy could inhibit tumor cells′radiation damage repair , reduce the proportion of hypoxic cells which is not sensitive to radiotherapy and promote the tumor cells entering into the radi -ation sensitive cell cycle synchronously .Most think that the effect of concurrent chemoradiotherapy program based on cisplatin is better , concurrent chemoradiotherapy has more side effects than alone radiotherapy ,and its concrete usage is still in groping stage .

关 键 词：中晚期宫颈癌 同步放化疗 

分 类 号：R73[医药卫生—肿瘤]