腮腺嗜酸细胞癌的临床病理观察  

Primary oncocytic carcinoma of the salivary glands:clinical and pathologic study of 2 cases

作　　者：洪良利[1] 秦杰升[2] 黄杰雄[1] 

机构地区：[1]汕头大学医学院第一附属医院病理科,广东汕头515041 [2]汕头大学医学院第一附属医院耳鼻喉头颈外科,广东汕头515041

出　　处：《现代肿瘤医学》2014年第5期1038-1040,共3页Journal of Modern Oncology

摘　　要：目的:观察腮腺嗜酸细胞癌(oncocytic carcinoma)的临床病理组织学特征、诊断与鉴别诊断,探讨其治疗与预后。方法:对2例腮腺嗜酸性细胞癌进行临床、病理组织学形态观察,并进行随访。结果:腮腺嗜酸细胞癌临床多表现为腮腺区无痛性、不规则肿块或颈淋巴结肿大。病理学表现为嗜酸性大细胞,异形性明显,核仁显著和浸润性生长特征。首次手术彻底切除是嗜酸细胞癌的首选治疗方法,术后可结合放疗。2例患者随访6-33个月,均未发现复发或转移。结论:腮腺嗜酸细胞癌是一种罕见的头颈部恶性肿瘤,容易误诊或漏诊,需要与嗜酸细胞腺瘤、腺泡细胞癌、腺样囊性癌、黏液表皮样癌等鉴别。治疗首选根治性手术。肿瘤大小、手术彻底与否和颈部淋巴结有无转移等与预后有关。Objective：To exPlore the clinicoPathologic features,diagnosis and differential diagnosis of oncocytic carcinoma in the Parotid gland. Methods：Two cases of oncocytic carcinoma were rePorted. The clinical data,Patholog-ical and immunohistochemical features were reviewed and discussed with the relevant literature. Results：Oncocytic carcinoma was mainly found as a Painless,irregular - shaPed mass or lymPhadenectasis in Parotid gland region. It is a rare Proliferation of malignant oncocytes with Prominent nucleoli and infiltrative qualities. Surgery was the PrinciPle treatment,and PostoPerative radiotheraPy was used as adjuvant treatment. There were no comPlications and no sign of recurrence of the two cases with follow - uP for 6 to 33 months. Conclusion：Oncocytic carcinoma is an extremely rare malignancy in head and neck. Differential diagnoses included oncocytic adenoma,acinic cell carcinoma,mucoePder-moid carcinoma. Radical resection with PostoPerative radiotheraPy is the main treatment. The Prognosis of oncocytic carcinoma may be associated with tumor stage,regional lymPh node metastases and comPlete surgical excision.

关 键 词：嗜酸细胞癌 腮腺 临床病理 

分 类 号：R739.87[医药卫生—肿瘤]