放疗同步TNF方案治疗鼻咽癌的临床疗效观察  

The effects of radiotherapy combined with TNF chemotherapy in advanced nasopharyngeal carcinoma(NPC)

作　　者：王娟毅[1] 马武[1] 景文江[1] 齐宝华[1] 马军[1] 杨晓君[1] 张淑莲[1] 

机构地区：[1]西安交通大学医学院附属3201医院肿瘤科,陕西汉中723000

出　　处：《现代肿瘤医学》2014年第5期1043-1045,共3页Journal of Modern Oncology

摘　　要：目的:观察放疗同期紫杉醇+奈达伯+氟尿嘧啶化疗治疗鼻咽癌的疗效及毒副反应。方法:81例确诊为鼻咽癌的患者随机分为治疗组(放疗同期TNF方案化疗组)41例和对照组(单纯放疗组)40例。治疗组在放射治疗的第1、4周给予TNF方案化疗及放疗后2个周期紫杉醇+奈达伯+氟尿嘧啶方案化疗。结果:治疗组1、3年生存率分别为100%(41/41)、82.9%(34/41)。对照组1、3年生存率分别为87.5%(35/40)、62.5%(25/40)(P>0.05)。放化组3年生存率及局控率、远处转移控制率明显高于单纯放疗组,治疗组虽消化道反应及骨髓功能抑制明显较对照组发生率高,但与对照组相比无统计学差异。结论:放疗同期TNF化疗治疗鼻咽癌疗效好,毒副反应可耐受。Objective：To observe the theraPeutic effects and side effects of radiotheraPy in advanced nasoPharyn-geal carcinoma（NPC）. Methods：A total of 81 advanced NPC Patients were randomly allocated into CRT grouP and RT grouP. The Patients in CRT grouP were treated by radiotheraPy combined with four cycles of TNF（chemotheraPy, of which two cycles were given in the 1th and 4th week during RT and the other two after RT. The Patients in RT grouP were treated by radiotheraPy alone. Results：CRT grouP 1,3 - year survival rates were 100%（41 / 41）,82. 9%（34 / 41）. The RT grouP 1,3 - year survival rates were 87. 5%（35 / 40）,62. 5%（25 / 40）（P ﹥ 0. 05）. ComPared with RT grouP,the 3 - year rate of survival,loco - control and metastasis in CRT grouP was significantly higher. The incidence of gastrointestinal and hematological toxicity in CRT were higher than that in RT,but without significant difference. Conclusion：The effects of radiotheraPy combined with TNF chemotheraPy in advanced nasoPharyngeal car-cinoma（NPC）is satisfied and toxicity were tolerable.

关 键 词：放疗 鼻咽癌 疗效 

分 类 号：R730.5[医药卫生—肿瘤] R739.63[医药卫生—临床医学]