FoxM1在消化系统肿瘤中的研究进展  

Research advancement of FoxM1 in digestive system tumors

作　　者：陈晓宇[1] 黄陈[1] 裘正军[1] 

机构地区：[1]上海交通大学附属第一人民医院普外科,上海200080

出　　处：《现代肿瘤医学》2014年第5期1188-1191,共4页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81101844;8121010802 7);上海市人才发展资金项目(编号:2012040);上海市浦江人才计划项目(编号:13PJD024);上海市卫生系统优秀青年人才培养计划(编号:XYQ2013092);上海交通大学晨星青年学者项目

摘　　要：FoxM1(Forkhead box protein M1)是一种转录因子蛋白质,具有调节细胞周期等重要作用。FoxM1与恶性肿瘤尤其是消化道肿瘤的发生、发展和转移密切相关。本文介绍FoxM1的结构和功能以及在肿瘤中的作用,重点综述FoxM1在消化系统肿瘤的表达及其临床意义,并展望FoxM1在消化系统肿瘤中的应用前景。FoxM1 is a transcriPtion factor Protein which Plays an imPortant role of regulation of the cell cycle. There-fore,FoxM1 is closely related to cancer Pathogenesis,develoPment and metastasis. This review aims to recommend the characteristics and functions of FoxM1 and its roles in tumor develoPment. FoxM1 exPression and clinical significance in digestive system tumors was reviewed mainly. Finally,the aPPlication ProsPect of FoxM1 in digestive system tumors was viewed.

关 键 词：FOXM1 消化系统肿瘤 研究进展 

分 类 号：R735[医药卫生—肿瘤]