基质金属蛋白酶-9和D-二聚体在卵巢癌诊断中的作用  

Value of matrix metalloproteinase-9 and D-dimer to the diagnosis of ovarian cancer

作　　者：孙伟娜[1] 杨海青[1] 陈院朝[1] 王升[1] 蔡文杰[1] 齐惠丽[1] 吴莎莎[1] 

机构地区：[1]安阳地区医院临床实验室,河南安阳455000

出　　处：《中华实用诊断与治疗杂志》2014年第5期492-493,共2页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨基质金属蛋白酶-9和D-二聚体在卵巢癌诊断及鉴别诊断中的意义。方法卵巢癌早期（I～1I）期患者21例（卵巢癌早期组）、卵巢癌晚期（Ⅲ～Ⅳ期）患者18例（卵巢癌晚期组）和巧克力囊肿患者42例（巧克力囊肿组），采用ELISA法检测各组基质金属蛋白酶-9和D-二聚体水平并进行比较。结果卵巢癌早期组外周血基质金属蛋白酶-9和D二聚体水平分别为（154.87±49.68）μg／L和（641.42±176.38）μg／L，卵巢癌晚期组分别为（187.56±50.21）μg／L和（954.67±285.43）μg／L，巧克力囊肿组分别为（78.69±33.54）μg／L和（66.88±31.26）μg／L），卵巢癌早、晚期组高于巧克力囊肿组（P〈0.01），卵巢癌晚期组明显高于卵巢癌早期组，差异均有统计学意义（P〈0.01）。结论基质金属蛋白酶-9和D-二聚体参与了卵巢癌的发生、发展，早期检测对卵巢癌诊断和鉴别诊断有重要价值。Objective To explore the clinical significance of matrix metalloproteinase-9 （MMP-9） and D dimer in the diagnosis and differential diagnosis of ovarian cancer. Methods The contents of MMP-9 and D-direct were detected by ELISA technique and compared among 42 patients with chocolate cyst （cyst group）, 21 patients with FIGO I to II stage （early cancer group） and 18 patients with FIGO III to IV stage （advanced cancer group）. Results The contents of MMP-9 and D-dimer were （154. 87± 49. 68） μg/L and （641. 42 ± 176. 38） μg/L in early cancer group, and were （187.56±50.21） μg/L and （954. 67±285.43） μg/L in advanced cancer group, significantly higher than those in cyst group （（78.69±33.54） μg/L, （66.88±31.26）μg/L） （P〈0.01）. Conclusions MMP-9 and D-dimer participate the development and progression of ovarian cancer, and the early detection has a great value to the diagnosis and differential diagnosis.

关 键 词：卵巢癌 基质金属蛋白酶9 D-二聚体 

分 类 号：R737.31[医药卫生—肿瘤]