大肠癌血清中12种肿瘤标志物最优诊断组合的建立及其相关性  

Construction of 12 tumor marker combination optimized in colon cancer serum for diagnosis and relative analysis

作　　者：钟志[1] 梁欢[1] 杨桐树[1] 杨丹[1] 彭士云[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院检验科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2014年第2期135-139,共5页Practical Oncology Journal

摘　　要：目的：探讨C12肿瘤标志物蛋白芯片监测系统中12种肿瘤标志物在大肠癌患者血清中的表达情况，筛选出对诊断最有意义的标志物。方法采用c12肿瘤标志物蛋白芯片检测系统测定60例大肠癌和40例健康对照者血清中12种肿瘤标志物，找出与大肠癌相关性最强的肿瘤标志物，计算各标志物组合方式对提高诊断率的贡献。结果 CEA＋CA199＋CA242＋Bete-HCG组合为诊断大肠癌效率最高的组合，联合检测可以提高诊断的灵敏度。最优诊断组合与患者年龄、性别、分化程度、病理类型、淋巴结转移、分期无明显相关。结论血清中CEA＋CA199＋CA242＋Bete-HCG联合检测可以作为大肠癌诊断的指标，联合检测可以提高诊断效率。Objective The purpose of this study is to explore the expression of 12 tumor Markerss in the serum of colon cancer patients by C 12 tumor marker protein chip ,screening most valuable Markers for diagnosis . Methods C12 tumor Marker of protein chips were used for 12 sorts of tumor marker detection among 60 CRC patients and 40 healthy controls ,address the most valuable tumor marker relative to colon cancer and contribution of combinations effect on diagnosis .Result CEA＋CA199＋CA242＋Bete-HCG combination diagnosis has the highest effectivity and diagnosis sensitivity was greatly improved by combination detection .The optimized diagno-sis showed no significant tendency to be correlated with age ,sex,differentiation stage,pathology,Lymph node me-tastasis,clinical stage.Conclusion It is of importance to use sera CEA ＋CA199＋CA242＋Bete-HCG detec-tion as markers for colon cancer diagnosis ,which may improve diagnosis efficiency .

关 键 词：结直肠癌 肿瘤标志物 临床分期 早期诊断 蛋白芯片 

分 类 号：R735.35[医药卫生—肿瘤]