N-芳基马来海松酸二酰亚胺位阻异构化研究  

Maleopimaric N-arylimides Atropisomeric Reaction and Their Kinetics Analysis

作　　者：金乐[1] 朱永涛[1] 姚贵阳[1] 李亚军[1] 王恒山[1] 

机构地区：[1]广西师范大学化学与药学学院,广西桂林541004

出　　处：《广西师范大学学报（自然科学版）》2014年第1期81-86,共6页Journal of Guangxi Normal University:Natural Science Edition

基　　金：广西科学研究与计划课题资助项目(桂科攻12118008-10)

摘　　要：以一级松香与马来酸酐进行Diels-Alder的加成产物马来海松酸酐为原料,制备一系列N-芳基马来海松香二酰亚胺,纯化得到光学纯的N-(1-萘基)马来海松酸二酰亚胺(3)及其甲酯(4),并通过IR、1 H及13 C NMR、MS等方法对目标化合物的结构进行鉴定和表征。发现其在结晶条件下为单一的trans构型,在溶剂中溶解过程中,化合物的N-芳基能够绕C—N键进行构型的翻转,具有位阻异构化的变旋现象,并利用旋光度和圆二色谱等手段确定了其在溶液中构型和变旋行为。A series of N-aromatic maleimide pine incense diimide derivatives were designed and synthesized using maleic anhydride as raw materials through Diels-Alder reaction. Their structures were confirmed using MS,IR,1H NMR and 13C NMR analysis. Compound 3 and compound 4 were evaluated for steric isomers activity using circular dichroism assay. It was found that they can change their configuration.

关 键 词：N-芳香基马来海松香二酰亚胺 位阻异构 旋光度 红外光谱 

分 类 号：O621.2[理学—有机化学]