联合检测血清CA72-4、MG-Ag和CA19-9对早期胃癌术后复发的预测价值  被引量:12

Combined detection of serum CA72-4,MG-Ag and CA19-9 in predicting postoperative recurrence of patients with Early gastric cancer

在线阅读下载全文

作  者:张科 谭红霞 卢建刚 胡孝海[2] 

机构地区:[1]重庆市涪陵区中心医院老年科,重庆408000 [2]广东省深圳市坪山新区人民医院急诊科,广东深圳518000

出  处:《海南医学院学报》2014年第6期773-775,778,共4页Journal of Hainan Medical University

基  金:深圳市龙岗区科技计划项目(YS2013117)~~

摘  要:目的:探讨血清糖类抗原72-4(CA72-4)、胃癌相关抗原(MG-Ag)和糖类抗原19-9(CA19-9)单独或联合检测对早期胃癌术后复发的预测价值。方法:281例经病理学确诊的早期胃癌术后患者作为研究对象,分为复发组与未复发组,检测血清CA72-4、MG-Ag和CA19-9的水平。结果:复发组血清CA72-4、MG-Ag和CA19-9水平及阳性率显著高于未复发组(P<0.05);单独血清CA72-4、MG-Ag、CA19-9检测及两两联合CA72-4+MG-Ag、MG-Ag+CA19-9及CA72-4+CA19-9预测早期胃癌术后早期复发的敏感性、特异性和准确性低于3项联合CA72-4+MG-Ag+CA19-9检测的敏感性、特异性和准确性。结论:早期胃癌术后复发患者的血清CA72-4、MG-Ag和CA19-9水平及阳性率高于未复发的患者,联合检测CA72-4、MG-Ag和CA19-9比单独或两两联合对早期胃癌术后复发有更高的预测价值。Objective: To investigate value of combined detection of serum CA72-4, MG-Ag and CA19-9 in predicating postoperative recurrence of patients with Early gastric cancer. Methods. A total of 281 patients with early gastric cancer were selected, and were divided into non-recurrence group and recur- rence group. Serum level of CA72-4, MG-Ag and CA19-9 were detected. Results: Levels and positive rate of serum CA72-4, MG-Ag and CA19-9 in recurrence group were sigr/ificantly higher than these in non recurrence group (P〈0.05). Sensitivity, specificity and accuracy of c0mhined detection of serum CA72-4+ MG-Ag+ CA19-9 were higher than single detection (CA72-4, MG-Agor CA19-9 )or combination detec- tion of two of them( CA72-4+ MG-Ag, MG-Ag+ CA19-9 or CA72-4+ CA19-9). Conclusion. Levels and the positive rate of serum CA72-4 ,MG-Ag and CA19-9 in early gastric cancer patients with postoperative recurrence are higher than these in non recurrence patients. CA72-4+ MG-Ag+ CA19-9 detection is more effective than single detection of CA72-4, MG-Ag or CA19-9 or combination detection of two of them( CA72-4+ MG-Ag, MG-Ag+ CA19-9 or CA72-4+ CA19-9).

关 键 词:糖类抗原72—4(CA72—4) 胃癌相关抗原(MG—Ag) 糖类抗原19—9(CA19—9) 胃癌 预后 

分 类 号:R735.2[医药卫生—肿瘤]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象