IL-23/IL-17免疫调节与慢性牙周炎  

IL-23 /IL-17 immune regulation in chronic periodontitis

作　　者：任东萍[1] 耿宁[1] 陈宇[1] 

机构地区：[1]口腔疾病研究国家重点实验室,四川大学华西口腔医学院,四川成都610041

出　　处：《实用医院临床杂志》2014年第3期8-10,共3页Practical Journal of Clinical Medicine

摘　　要：慢性牙周炎病因复杂,对于其发病机制目前尚不是很明确。对于新近发现的与白细胞介素-23(IL-23)相关能分泌白细胞介素-17(IL-17)的CD4+T细胞亚群即Th17细胞,或许能为我们提供新的思路。下面就慢性牙周炎的发病机制、研究现状、IL-23/IL-17与慢性牙周炎致病因子的关系及此免疫通路活化在慢性牙周炎致病过程中所起的作用作一综述。The etiology of chronic periodontitis is complex and its pathogenesis remains unclear .Help T cell 17 （ Th17 ） is a newly discovered subset of T cells associated with interleukin-23（IL-23）and characterized by production of interleukin 17（IL-17）.IL-17 has protective effects by facilitating pro-inflammatory responses .These discoveries may lead to an improved understanding of disease pathogenesis .In this article ,we will review the pathogenesis of chronic periodontitis ,the research status and the relationship between IL-23/IL-17 and pathological factors as well as the role of activation of its immune single pathway in process of chronic periodontitis .

关 键 词：慢性牙周炎 TH17细胞 白细胞介素-23 白细胞介素-17 

分 类 号：R781.42[医药卫生—口腔医学]