静电纺丝聚乳酸-羟基乙酸纳米纤维膜与磷酸钙骨水泥复合物力学性能的研究  

Mechanical property of a compound of electrospun PLGA nanofiber membrane and CPC

作　　者：黄琳惠[1] 麦煜颖 陆建志[1] 张天[1] 廖红兵[1] 

机构地区：[1]广西医科大学口腔医学院,广西南宁530021

出　　处：《实用医院临床杂志》2014年第3期32-34,共3页Practical Journal of Clinical Medicine

基　　金：广西卫生医疗重点课题资助项目(编号:2012017)

摘　　要：目的模仿天然骨同心圆的结构,制备静电纺丝聚乳酸-羟基乙酸共聚物[Poly(lactide-co-glycolide acid),PLGA]纳米纤维膜/磷酸钙骨水泥(calcium phosphate cement,CPC)复合物,通过力学实验初步探讨静电纺丝PLGA纳米纤维膜改善CPC韧性强度的效果。方法实验分为两组:实验组为CPC/PLGA复合物、对照组为单纯的CPC,将CPC复合物或单纯的CPC制备6 mm×6 mm×20 mm的长方体试件,进行三点弯曲试验测试材料的韧性强度、弯曲强度和弹性模量。结果与CPC组相比较,CPC/PLGA组的韧性强度提高了71.4倍,差异具有统计学意义(P=0.00);弯曲强度提高28.8%,弹性模量降低37.8%,差异无统计学意义(P>0.05)。结论静电纺丝PLGA纳米纤维膜可以改善CPC的韧性,静电纺丝PLGA纳米纤维膜/CPC复合物具有较好的力学特性。Objective A compound of Poly（lactide-co-glycolide acid） （PLGA）and calcium phosphate cement（CPC） was pre- pared that imitated the concentric structures Of natural bone. Then, the effect of electrospun PLGA nanofiber membrane on toughness strength of CPC was explored by using a mechanical experiment. Methods The PLGA/CPC compound or pure CPC were prepared to be cuboid specimens with size of 6 mm×6 mm×20 mm. The toughness strength, bending strength and modulus of elasticity of the materi- als were tested by the three-point flexural test. Results The toughness strength of the PLGA/CPC compound was 71.4 times higher than that of the pure CPC （P = 0. 00）. However,there were no significant difference in the bending strength and modulus of elasticity although the former was increased by 28.8% while the latter was reduced by 37.8%. Conclusion Electrospun PLGA nanofiber mem- brane can improve the toughness of CPC, and the compound shows a good mechanical property.

关 键 词：磷酸钙骨水泥 聚乳酸-羟基乙酸共聚物 静电纺丝 力学性能 

分 类 号：R783.1[医药卫生—口腔医学]