首发重性抑郁障碍静息态脑功能局部一致性及低频振幅研究  

Resting state functional magnetic resonance imaging in patients with first-episode major depression disorder

作　　者：赵冰[1,3] 魏国强 侯丽英 徐成[2] 张克让[3] 

机构地区：[1]山西省长治市人民医院神经内科,046000 [2]山西省人民医院核磁共振室 [3]山西医科大学第一医院精神卫生科

出　　处：《中华行为医学与脑科学杂志》2014年第4期334-337,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金面上项目（30971054,81171290）

摘　　要：目的 利用脑功能磁共振方法研究首发重性抑郁障碍患者静息态脑功能活动特征,探讨重性抑郁障碍患者静息态下异常活动的脑区.方法 对51例符合美国精神障碍诊断与统计手册第4版诊断标准的首发未用药重性抑郁障碍患者（病例组）与50例性别、年龄、文化程度相匹配的健康志愿者（对照组）进行静息态功能磁共振扫描,以汉密尔顿抑郁量表评估患者临床症状,计算其全脑的局部一致性与低频振幅.结果 病例组较对照组局部一致性增高的脑区有右侧额叶内侧回（BA6,MNI坐标3,-3,63,K=34）与左侧额叶内侧回（BA9,MNI坐标-9,36,30,K=10）,两组之间差异有统计学意义（P＜0.001,未校正）;病例组较对照组低频振幅增高的脑区有右侧额叶内侧回（BA6,MNI坐标3,-3,63,K=35）与右侧后扣带回（BA31,MNI坐标3,-36,36,K=11）,两组之间差异有统计学意义（P＜0.001,未校正）.结论 首发重型抑郁障碍患者在静息态存在多个脑区功能活动的异常,并可能与抑郁障碍的病理机制有关.Objective To explore the abnormally functional brain region in resting state in first-episode major depression disorder patients with function magnetic resonance imaging.Methods 51 patients diagnosed with first-episode major depression disorder according to DSM-Ⅳ and 50 gender-,age-,and education-matched healthy controls completed resting state fMRI scan.The severity of depression,and unpredicted homodynamic responses across the whole brain were analyzed using Hamilton depression scale,regional homogeneity and amplitude of low-frequency fluctuation,respectively.Results Compared with control group,the right medial frontal gyms （BA6,MNI：3,-3,63,K=34） and left medial frontal gyrus（BA9,MNI：-9,36,30,K=10） （P〈0.001,uncorrected） in the case group showed higher regional homogeneity,with statistical significance.Compared with control group,right medial frontal gyrus （BA6,MNI：3,-3,63,K =35） and right posterior cingulated gyrus （BA31,MNI：3,-36,36,K =11） （P〈 0.001,uncorrected）in the case group showed higher amplitude of low-frequency fluctuation,with statistical significance.Conclusion First-episode major depression disorder patients in resting state had several abnormally functional brain regions,which might be related to the pathological mechanism of depression disorder.

关 键 词：抑郁障碍 功能磁共振成像 静息态 局部一致性 低频振幅 默认状态网络 

分 类 号：R749.4[医药卫生—神经病学与精神病学]