TWIST基因及其在骨肉瘤中的研究进展  

Research process for TWIST gene in osteosarcoma

作　　者：周勇[1] 石坚[1] 张朝跃[1] 

机构地区：[1]中南大学湘雅三医院骨科,长沙410013

出　　处：《中华临床医师杂志（电子版）》2014年第6期143-146,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：TWIST是近年来新发现的一种癌基因蛋白,其被认为在包括骨肉瘤等在内的多种恶性肿瘤的发生、发展中起着重要的作用。骨肉瘤是骨恶性肿瘤中最多见的一种,由间质细胞系发展而来,其生长迅速,恶性程度高,预后较差。本文主要综述TWIST基因在临床方面的意义以及其在骨肉瘤发生发展过程中的作用,将为今后骨肉瘤的诊断、治疗与科学研究提供新的方向与指导。TWIST is the new-found oncogene protein which was believed to play a prominent part in oncogenesis and tumor progression. Osteosarcoma is the most common tumor in the skeletal system which grows promptly with high degree of malignancy and poor prognosis. This paper mainly summarized TWIST gene in terms of clinical significance as well as the role it plays in the process of the occurrence and development of osteosarcoma, and will give a new direction for diagnosis and treatment of osteosarcoma and scientific research in the future.

关 键 词：骨肉瘤 TWIST基因 研究进展 

分 类 号：R738[医药卫生—肿瘤]