熊果酸对大鼠体内瑞舒伐他汀的药代动力学影响  

Effect of Ursolic Acid on Pharmacokinetics of Rosuvastatin in Rats

作　　者：温金华[1] 汪安江[1] 邹德琴[1] 赖永全[1] 郑雪莲[1] 熊玉卿[2] 

机构地区：[1]南昌大学第一附属医院药剂科 [2]南昌大学临床药理研究所,南昌330006

出　　处：《南昌大学学报（医学版）》2014年第2期1-4,共4页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金青年项目(81202583);江西省教育厅青年基金(GJJ12145)

摘　　要：目的：探讨熊果酸对大鼠体内瑞舒伐他汀的药代动力学影响。方法12只雄性 SD 大鼠（200～235 g）按随机数字表法分为2组，分别为单用瑞舒伐他汀组与瑞舒伐他汀合用熊果酸组，每组6只，以瑞舒伐他汀100 mg· kg^-1、熊果酸80 mg·kg^-1的剂量灌胃给药，两药合用时先熊果酸后瑞舒伐他汀相继灌胃。采用 LC-MS 测定血药浓度，比较2组间药代动力学参数。结果合用熊果酸后，瑞舒伐他汀药代动力学参数 Cmax、AUC0-t、AUC0-∞参数值分别增加163．02％、145．99％和157．55％，而 CLz/F 值降低了57．84％（P ＜0．05或 P ＜0．01）。结论熊果酸可影响大鼠体内瑞舒伐他汀的药代动力学特性。Objective To study the effect of ursolic acid on the pharmacokinetics of rosuvasta-tin in rats.Methods Twelve male rats（200-235 g）were randomly given rosuvastatin alone（control group）or in combination with ursolic acid（treatment group）,with 6 rats in each group.Rosuvastatin（100 mg·kg^-1 ）,ursolic acid（80 mg·kg^-1 ）were adiministered by intragastric adminis-tration.Combination of both recipes were adiministered first ursolic acid.LC-MS was used to determine the plasma concentrations of rosuvastatin.Pharmacokinetic parameters were compared between the two groups.Results Compared with control group,Cmax ,AUC0-t and AUC0-∞ parameters were respectively increased by 163.02%,145.99% and 157.55%,but CLz/F was decreased by 57.84% in treatment group（P 〈0.05 or P〈0.01）.Conclusion Ursolic acid can affect the pharmacokinetic properties of rosuvastatin in rats.

关 键 词：熊果酸 瑞舒伐他汀 药代动力学 

分 类 号：R-332[医药卫生] R969.1