2～3岁孤独谱系障碍儿童尾状核体积与重复刻板行为的关系  

Correlation between caudate nucleus volume and repetitive behaviors in 2 to 3 year old children with autism spectrum disorder

作　　者：邱婷[1] 钱璐[1] 肖湘[1] 肖运华 肖婷[1] 肖朝勇[1] 邹冰[1] 方慧[1] 储康康[1] 张久平[1] 柯晓燕[1] 

机构地区：[1]南京医科大学附属脑科医院儿童心理卫生中心

出　　处：《临床精神医学杂志》2014年第2期83-85,共3页Journal of Clinical Psychiatry

基　　金：国家自然科学基金重大计划培育项目(项目号:91132705);江苏省科技厅自然科学基金资助项目(项目号:BK2012519);江苏省医学重点人才(项目号:RC2011024)

摘　　要：目的:对比2～3岁孤独谱系障碍(ASD)与发育迟缓(DD)儿童尾状核体积的差异,并探讨尾状核体积与重复刻板行为严重程度的关系。方法:使用ITK-SNAP软件分别计算并比较66例ASD儿童(ASD组)和36例年龄、性别、智商与之相匹配的DD儿童(DD组)的尾状核体积,并与由孤独症诊断访谈量表-修订版(ADI-R)所得重复刻板行为分数进行相关分析。结果:ASD组尾状核左侧(P=0.005)、右侧(P<0.001)以及总体积(P=0.001)较DD组显著增大;尾状核左侧(r=0.359,P=0.004)、总体积(r=0.317,P=0.013)与ADI-R低水平重复刻板行为分呈显著正相关。结论:2～3岁的ASD儿童已表现出尾状核体积的异常增大,且与低水平的重复刻板行为有相关。Objective：To explore the caudate nucleus volume between the autism spectrum disorder （ASD）and developmental delay（DD）groups,and determine the relationship between caudate nucleus volume and restricted,repetitive behavior（RRB）in 2-to 3-year old children with ASD. Method：Caudate nucleus volume,quantified by ITK-SNAP,was compared between 66 children with ASD and 36 age,gender and intelligence-matched control children with DD aged 2-to 3-years. The relationship between caudate nucleus volume and RRB scores of autism diagnostic interview-revised（ADI-R）was analyzed. Results：The volumes of left （P = 0. 002）,right（P ﹤ 0. 001）and total（P = 0. 001）caudate nucleus were significantly larger in the ASD group compared to the DD group. In ASD group,left（r = 0. 329,P = 0. 004）and total（r = 0. 317,P = 0. 013） caudate nucleus volumes were significantly associated with lower order RRB scores. Conclusion：The caudate nucleus volume in 2 to 3 year old children with ASD is incresed and correlated with lower order repetitive behaviors.

关 键 词：孤独谱系障碍 尾状核体积 重复刻板行为 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]