青春前期女童口服铁剂吸收利用的动力学研究  

Study on efficiency of iron utilization in prepubertal female children

作　　者：张宇[1] 杨丽琛[1] 朴建华[1] 黄振武[1] 朱红[1] 杨晓光[1] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所,北京100050

出　　处：《卫生研究》2014年第3期353-356,共4页Journal of Hygiene Research

摘　　要：目的探讨青春前期女性儿童铁的利用率情况。方法在常规膳食模式下，以57Fe为示踪剂，27名10～12岁女性儿童为受试对象，分别在口服示踪剂前、14天后和28天后采集静脉血分离红细胞。样品经消化后分别测定其铁含量及同位素丰度，计算并分析受试者57Fe在红细胞中掺入情况。结果14天和28天红细胞内57Fe与摄入总量比值分别为（19．84±0．53）％和（18．75±0．40）％（P〉0．05），红细胞内57Fe与全血中57Fe量比值分别为（93．49±2．27）％和（88．73±0．43）％，14天红细胞掺入率显著高于28天时（P〈0．05）。结论以单标稳定同位素示踪评价青春前期女性儿童红细胞掺入率，可反映受试者体内铁的利用情况。青春前期女性儿童铁的利用率普遍较高，给予示踪剂后14天可作为红细胞掺入率研究的切入点。Objective To investigate the iron utilization of prepubertal female children. Methods 27 female children from 10 to 12 years old were selected and given 57Fe as a tracer, in conventional diet mode, the blood samples in 1 day before test, 14 days and 28 days after tracer given were taken, and were conducted into red blood cell sample. The iron content and changes of isotope abundance in samples were analyzed and combined with blood volume to get the utilization of iron in RBC. Results The erythrocyte incorporation rate（ of dose） in 14 days and 28 days were （19.84 ± 0.53）% and （18.75 ± 0.40）% （P 〉 0.05）. The erythrocyte incorporation rate（ of absorption） were （93.49 ± 2.27） % and （88.73 ± 0.43 ） % respectively, and there was a significantly difference （ P 〈 0.05 ）. Conclusion It is feasible and accurate to evaluate the iron utilization using erythrocyte incorporation rate, which is tested by single stable children has a higher utilization of iron, entry point in erythrocyte incorporation isotopes tracer technique. Prepubertal female and the 14 days after tracer given is a effective study.

关 键 词：青春前期 女性儿童 铁 红细胞掺入率 稳定同位素示踪 

分 类 号：R151.43[医药卫生—营养与食品卫生学] Q591.1[医药卫生—公共卫生与预防医学]