预防性抗癫痫治疗在高级别胶质瘤患者中作用的研究  

A case-control study of prophylactic antiepileptic therapy in patients with high-grade gliomas

作　　者：李毅毅[1] 荆国杰[1] 祝刚[2] 姚晓腾[1] 

机构地区：[1]广东省惠州市第一人民医院神经外科,广东惠州516000 [2]广东省惠州市中心人民医院神经外科,广东惠州516000

出　　处：《中国现代医学杂志》2014年第7期84-87,共4页China Journal of Modern Medicine

摘　　要：目的评估预防性抗癫痫治疗在无癫痫病史的恶性胶质瘤患者中的价值。方法采用回顾性病例对照研究,患者分为两组:一组术前进行了预防性抗癫痫治疗,另一组未进行治疗。选用左乙拉西坦(levetiracetam,LEV)作为抗癫痫药。应用Logistic回归模型分析各组的优势比(OR)。自变量包括治疗方法、性别、年龄和肿瘤位置。观测指标为术后6个月内是否有癫痫发作。结果虽然给予左乙拉西坦后癫痫发作风险的回归系数略降低,但左乙拉西坦预防用药不是癫痫发作与否的显著预测因子,而患者年龄却是其显著预测因子———年轻患者术后6个月发生癫痫的风险更高。结论术前预防性应用抗癫痫药对高级别胶质瘤患者无明确效果,不应常规应用。[ Objective ] To assess the application value of prophylactic antiepileptic treatment in malignant glioma patients with no epileptic seizure. [Methods ] A retrospective case-control study was conducted. The subjects were divided into two parts： one received prophylactic antiepileptic treatment and the other did not. We used logistic regression model to analysis the odds ratios. The independent variables consisted of therapeutic method, age, sex, location of tumor. The index of therapeutic effect was whether seizure or not post-operatively. [ Results ] Pro- phylactic antiepileptic treatment was not a striking predictive factor of epileptic seizure. However, age of the patient was a significant predictive factor. The risk of seizure was higher in younger patients six months after surgery. [ Conclusions ] The therapeutic effect of preoperative prophylactic antiepileptic treatment was not satisfied and it should not be used routinely.

关 键 词：癫痫 胶质瘤 抗癫痫药 手术 病例对照研究 

分 类 号：R739.41[医药卫生—肿瘤]