乙肝病毒携带产妇感染状态与新生儿发生宫内感染的相关性分析  

A correlation study of the impact of maternal HBV infection on the intrauterus transmission to newborn infants

作　　者：王兰芳[1,2] 蔡娟[2] 何刘媛[2] 唐胜利[2] 王朝红[2] 朱建生[2] 沈继龙[1] 

机构地区：[1]安徽医科大学病原微生物学教研室,安徽病原生物学省级实验室,安徽合肥230032 [2]合肥市妇幼保健院,安徽合肥230001

出　　处：《中华疾病控制杂志》2014年第5期391-393,共3页Chinese Journal of Disease Control & Prevention

摘　　要：目的探讨孕妇乙肝感染状态与新生儿宫内感染的关系。方法将115例乙肝表面抗原(hepatitis B surface antigen,HBsAg)阳性的孕妇分为A组(乙肝HBsAg,HBeAg,HBcAb阳性组)、B组(乙肝HBsAg,HBeAb,HBcAb阳性组)、C组(HBsAg,HBcAb阳性组)、D组(HBsAg,HBeAg阳性组)。对上述部分孕妇进行乙肝两对半及PCR-HBV-DNA值的检测,对其所生的新生儿在出生后24 h内进行乙肝两对半的检测。结果乙肝大三阳(HBsAg,HBeAg,HBcAb阳性)孕妇与乙肝小三阳(HBsAg,HBeAb,HBcAb阳性)孕妇比较,新生儿发生宫内感染差异无统计学意义(P=0.256),乙肝孕妇体内HBV-DNA值>105基因拷贝/ml时发生新生儿宫内感染高于体内HBV-DNA值<105基因拷贝/ml(P=0.001)。结论乙肝大三阳孕妇或体内HBV-DNA载量高是新生儿宫内感染的危险因素,应及时给予阻断,产后及时采取联合免疫措施,减少乙肝患儿的发生。Objective To investigate the relationship between Hepatitis B Virus （HBV） infection of pregnant women and intrauterine HBV infection. Methods Based on the positive items of hepatitis B surface antigen（HBsAg） ex- amination, 115 cases of HBsAg positive pregnant women were divided into group A（ positive antigens of HBsAg, HBeAg and HBcAb） ; group B（ positive antigens of HBsAg, HbeAb and HBeAb） ; group C（positive antigens of HBsAg and HBcAb） ; and group D（ positive antigens of HBsAg and HBeAg）. The pregnant women and their newborn babies 24h after birth were detected for sera five antigens of hepatitis B. Results The pregnant women of group A and group B had no significant difference （P = 0. 256 ） in neonatal intrauterine infection, The women with 〉 10^5 HBV-DNA copies/ml sera had a higher probability than those who had 〈 10^5 HBV-DNA copies/ml sera（ P = 0. 001 ）to give birth to the babies with intrauterine in- fection. Conclusions The high load of maternal hepatitis B HBeAg or HBV-DNA is one of the risk factors for intrauterine infection of newborn infants. Measures should be taken to block the intrauterine infection and postpartum take timely meas- ures of combined vaccinations should be taken to reduce the congenital neonatal HBV infection after birth.

关 键 词：肝炎 乙型 疾病传播 垂直 婴儿 新生 流行病学 

分 类 号：R575.1[医药卫生—消化系统] R722.1[医药卫生—内科学]