炎症性疾病相关microRNA的研究进展  

Research progress of microRNA in inflammatory diseases

作　　者：李忠旬 郑小莉[2] 刘佳佳[1] 

机构地区：[1]泸州医学院基础医学院免疫学教研室,646000 [2]泸州医学院基础医学院生物化学教研室,646000

出　　处：《国际免疫学杂志》2014年第3期179-182,共4页International Journal of Immunology

基　　金：国家自然科学基金（30371305）;四川省科技厅项目（2014JY0008）;泸州医学院院级基金重点项目

摘　　要：MicroRNA（miRNA）是一类长度约为18～24个核苷酸的非编码小RNA，通过与靶mRNA的3端非编码区域结合，降解mRNA或阻止mRNA的翻译，发挥负性调节作用。炎症是具有血管系统的活体组织对损伤因子发生的防御性反应，可以清除进入机体的有害物质，但有些时候却对机体自身发生反应而造成损伤。目前发现多种miRNA参与炎症性疾病的发生、发展过程，因此研究与炎症性疾病有关的miRNA对这些疾病的诊断和治疗有重要的意义。MircoRNA （miRNA） is a class of small non-coding RNAs with 18 - 24 nucleotides in length and targets the 3＇ Untranslased region, miRNA plays an important role in negative regulation through pro- moting the degradation of mRNA or preventing the translation of mRNA. Inflammation is a defensive reaction occurring in living tissues with vascular system. On one hand, inflammation protects the tissue from damage by clearing harmful factors. On the other hand, inflammation can cause tissue damage by releasing the bioactive substances form inflammatory cells. It has been found that many miRNAs are involved in the occurrence and de- velopment of inflammatory diseases. Therefore, the studies on the inflammation-related miRNAs is important for the diagnosis and treatment of inflammatory diseases.

关 键 词：炎症 MICRORNA 哮喘 类风湿关节炎 系统性红斑狼疮 

分 类 号：R363[医药卫生—病理学]